THE AMELIORATIVE EFFECTS OF LUPEOL AND FLUTAMIDE ON DEHYDROEPIANDROSTERONE-INDUCED UTERINE HYPERFIBROSIS IN MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

REZAEI GOLMISHEH ALI; SADRKHANLOU RAJAB ALI; MALEKINEJAD HASSAN; AHMADI ABBAS

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Studies in Medical Sciences Year:2017 | Volume:27 | Issue:10 Page(s): 923-934

Download Full-Text

Persian Verion

View:

888

Download:

Cites:

Information Journal Paper

Title

THE AMELIORATIVE EFFECTS OF LUPEOL AND FLUTAMIDE ON DEHYDROEPIANDROSTERONE-INDUCED UTERINE HYPERFIBROSIS IN MICE

Author(s)

REZAEI GOLMISHEH ALI | SADRKHANLOU RAJAB ALI | MALEKINEJAD HASSAN | AHMADI ABBAS | Issue Writer Certificate

Keywords

LUPEOLQ1

FLUTAMIDEQ1

UTERINE HYPERFIBROSISQ1

DEHYDROEPIANDROSTERONEQ1

Abstract

Background & Aims: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive ages that may contribute to uterine complications such as endometrial hyperplasia and hyperfibrosis. Hyperandrogenemia is the key factor in the pathophysiology of PCOS.Based on recent finding concerning anti-androgen effects of LUPEOL, we aimed to study the effects of this triterpenoid on uterine damages of hyperandrogenemia and compare them with FLUTAMIDE.Materials & Methods: Forty prepubertal female albino mice aged 25 days were randomly assigned to experimental groups. Control group (n=10) received 0.1 ml/day sesame oil (IP) for 35 consecutive days.The rest of animals received 60 mg/kg B.W./day DHEA dissolved in 0.1 ml sesame oil for twenty days and afterward for fifteen days each group (n=10) was treated either sesame oil [group PCOS (P)], LUPEOL 40 mg/kg B.W. (group L) or FLUTAMIDE 10 mg/kg B.W. (group F). Weight gains were recorded weekly.At the end of treatment animals were humanly euthanized under deep ether anesthesia and uterine samples were collected. Histological sections were prepared and stained with H& E, AZAN and Toluidine blue methods for histomorphometric, fibrosis and mast cells count analyses. Fibrosis quantification was performed based on image analysis using Matlab software (V.8.1.0).Results: At the end of treatment period, group P demonstrated remarkable increase of body weight whereas LUPEOL and FLUTAMIDE treatment decreased weight gain significantly (P<0.05). Endometrium thickness (mm), average percentage of collagen fibers in uterine tissue (%) and average number of mast cells in histological sections (n) in group P (331.6±63.8, 14.6±1.65, 3.02±0.89, respectively) increased significantly compared to group C (235.3±28.1, 8.10±1.41, 1.47±0.55) and decreased in L (199.8±51.3, 4.07±0.90, 1.02±0.69) and F (194.6±41.4, 5.21±0.39, 1.31±0.60) groups significantly compared to group P (P<0.05).Conclusion: We conclude that LUPEOL is able to reduce uterine hyper fibrosis and endometrial hyperplasia induced by DHEA in mice and these are similar to effects of FLUTAMIDE. These effects of LUPEOL could be in part because of its anti- androgen receptor effects.

Cites

No record.

References

Cite

APA: Copy

REZAEI GOLMISHEH, ALI, SADRKHANLOU, RAJAB ALI, MALEKINEJAD, HASSAN, & AHMADI, ABBAS. (2017). THE AMELIORATIVE EFFECTS OF LUPEOL AND FLUTAMIDE ON DEHYDROEPIANDROSTERONE-INDUCED UTERINE HYPERFIBROSIS IN MICE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 27(10), 923-934. SID. https://sid.ir/paper/64341/en

Vancouver: Copy

REZAEI GOLMISHEH ALI, SADRKHANLOU RAJAB ALI, MALEKINEJAD HASSAN, AHMADI ABBAS. THE AMELIORATIVE EFFECTS OF LUPEOL AND FLUTAMIDE ON DEHYDROEPIANDROSTERONE-INDUCED UTERINE HYPERFIBROSIS IN MICE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2017;27(10):923-934. Available from: https://sid.ir/paper/64341/en

IEEE: Copy

ALI REZAEI GOLMISHEH, RAJAB ALI SADRKHANLOU, HASSAN MALEKINEJAD, and ABBAS AHMADI, “THE AMELIORATIVE EFFECTS OF LUPEOL AND FLUTAMIDE ON DEHYDROEPIANDROSTERONE-INDUCED UTERINE HYPERFIBROSIS IN MICE,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 27, no. 10, pp. 923–934, 2017, [Online]. Available: https://sid.ir/paper/64341/en

Related Journal Papers