مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ABCG5 GENE RESPONSES TO TREADMILL RUNNING WITH OR WITHOUT ADMINISTRATION OF PISTACHIO ATLANTICA IN FEMALE RATS

Pages

  162-171

Abstract

 Objective (s): ABC TRANSPORTERS comprise a large family of transmembrane proteins that use the energy provided by ATP hydrolysis to translocate a variety of substrates across biological membranes. All members of the human ABCG subfamily, except for ABCG2, are cholesterol-transporter. The aim of this study was to determine the liver, the small intestine and kidney ABCG5 relative gene expression in response to treadmill-running training in FEMALE RATS.Materials and Methods: Twenty Wistar rats (6-8 weeks old and 125-135 g weight) were used. Animals were randomly assigned to saline-control (SC), saline-training (ST), and Baneh-control (BC), and Baneh-training (BT) groups. Training groups did the exercise on a motor-driven treadmill at 25 m/min (0% grade) for 60 min/day for eight weeks (5 days/week). Rats were fed orally, with Baneh extraction and saline for six weeks. The two-way ANOVA was employed for statistical analysis. ABCG5 relative gene expression was detected by Real-time PCR method.Results: The current findings indicate that the Baneh-treated tissues had significantly lower levels of ABCG5 gene expression in the liver, small intestine, and kidneys (P<0.001, P<0.003, P<0.001, respectively), when compared with saline-treated tissues. However, a higher level of gene expression was observed in exercise groups. A lower level of HDL-c but not triglyceride (TG) and total cholesterol (TC) levels were found in Baneh-treated animals at rest.Conclusion: Exercise training increases ABCG5 relative gene expression in the liver, small intestine and kidney tissues; therefore exercise training may adjust the reduction of ABCG5 relative gene expression in Baneh-training group.

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    • Cite

    APA: Copy

    GHANBARI NIAKI, ABBASS, ZARE KOOKANDEH, NAVABEH, & ZARE KOOKANDEH, ASGHAR. (2014). ABCG5 GENE RESPONSES TO TREADMILL RUNNING WITH OR WITHOUT ADMINISTRATION OF PISTACHIO ATLANTICA IN FEMALE RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(3), 162-171. SID. https://sid.ir/paper/643487/en

    Vancouver: Copy

    GHANBARI NIAKI ABBASS, ZARE KOOKANDEH NAVABEH, ZARE KOOKANDEH ASGHAR. ABCG5 GENE RESPONSES TO TREADMILL RUNNING WITH OR WITHOUT ADMINISTRATION OF PISTACHIO ATLANTICA IN FEMALE RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(3):162-171. Available from: https://sid.ir/paper/643487/en

    IEEE: Copy

    ABBASS GHANBARI NIAKI, NAVABEH ZARE KOOKANDEH, and ASGHAR ZARE KOOKANDEH, “ABCG5 GENE RESPONSES TO TREADMILL RUNNING WITH OR WITHOUT ADMINISTRATION OF PISTACHIO ATLANTICA IN FEMALE RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 3, pp. 162–171, 2014, [Online]. Available: https://sid.ir/paper/643487/en

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