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Information Journal Paper

Title

STUDY OF THE PREVALENCE OF HUMAN PAPILLOMAVIRUS TYPE 16 AND 18 AMONG PATIENTS WITH CERVICAL CANCER IN WEST AZERBAIJAN PROVINCE USING PCR METHOD

Pages

  414-421

Abstract

 Background & Aims: HUMAN PAPILLOMAVIRUSES (HPVs) are associated with cervical intraepithelial neoplasia and invasive carcinoma. Epidemiological data show that about 90% of all CERVICAL CANCER patients are HPV positive and HPV-16 is the most prevalent in CERVICAL CANCER, followed by HPV-18. As HPV subtypes has not been assessed in the West Azerbaijan province, therefore; the main focus of this study was to determine the prevalence of HPV 16 and 18 in cases of CERVICAL CANCER.Materials & Methods: Thirty six pathological blocks with uterine cervical carcinomas (SCC, CIN, CIS, Adenocarcinoma, etc.) who referred between 2000-2005 to a pathology unit were collected and their DNA was extracted. DNA was amplified using PCR method and subtypes of the virus were determined.Results: From 36 amplified samples with general primers, 30 samples (83.3%) were HPV positive and 6 samples were HPV negative (16.7%). Thirteen cases were HPV16 positive (36.1%). Neither of the cases were HPV 18 positive. The majority of tumors were squamous cell carcinomas (62.2%), and the rest were CIN I and LSIL (23.1%). There was a significant correlation between the presence of HPV and type of pathological findings since all SCC samples were HPV positive (P=0.007). Conclusion: Obtained results showed that HPV screening by PCR method especially screening subtype 16 in all cervical carcinoma samples is advisable in West Azerbaijan province.

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