STUDY OF DIURETIC EFFECTS OF ALBUMIN & FUROSEMIDE CO-ADMINISTRATION COMPARED TO FUROSEMIDE IN PATIENTS WITH THE NEPHROTIC SYNDROME

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GHAFARI MOGHADAM A.; MAKHDOUMI KH.; MAHDI ZADEH KHALIFANI A.R.

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Journal: Studies in Medical Sciences Year:2007 | Volume:18 | Issue:1 Page(s): 422-426

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Title

STUDY OF DIURETIC EFFECTS OF ALBUMIN & FUROSEMIDE CO-ADMINISTRATION COMPARED TO FUROSEMIDE IN PATIENTS WITH THE NEPHROTIC SYNDROME

Author(s)

GHAFARI MOGHADAM A. | MAKHDOUMI KH. | MAHDI ZADEH KHALIFANI A.R. | Issue Writer Certificate

Keywords

ALBUMINQ2

FUROSEMIDEQ3

NEPHROTIC SYNDROMEQ2

Abstract

Background & Aims: In patients with NEPHROTIC SYNDROME, the natriuretic effect of FUROSEMIDE (FU) is diminished. The effect of co administration of FU and human ALBUMIN (HA) has remained controversial.Material & Methods: In a cross-over clinical trial study, ten nephrotic patients (seven females, 33.57years) on standardized sodium chloride intake, in random order on three separate days, received by intravenous administration for 60 minutes either (a) 1 mg/kg FU plus a sham infusion, (b) 1mg/kg FU plus 200 ml of a 20% solution of HA, or (c) sham infusion plus 200 ml of a 20% solution of HA. Urinary volume and sodium excretion and glomerular filtration rate were assessed. Results: Mean 24h urine volume after infusion of HA, FU, and HA plus FU was 724ml (SD= 528), 1707ml (SD=745), 2175ml (SD=971), respectively (Pv=0.015). Mean FENa was 1.96% (SD=0.251), 3.18% (SD=0.25), 4.77% (SD=0.21) respectively, (Pv=0.015). Mean 24h urine Na was 118.3 (SD=6.86), 208.4 (SD=5.27), 206 (SD=8.45) respectively, (Pv=0.005). Mean GFR was 104.5, 96.6, 106.6 respectively, (Pv=0.021).Conclusion: Coadministration of HA potentates the action of FU in patients with NEPHROTIC SYNDROME by increasing effects on GFR and diuretic potency of FU.

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APA: Copy

GHAFARI MOGHADAM, A., MAKHDOUMI, KH., & MAHDI ZADEH KHALIFANI, A.R.. (2007). STUDY OF DIURETIC EFFECTS OF ALBUMIN & FUROSEMIDE CO-ADMINISTRATION COMPARED TO FUROSEMIDE IN PATIENTS WITH THE NEPHROTIC SYNDROME. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 18(1), 422-426. SID. https://sid.ir/paper/64395/en

Vancouver: Copy

GHAFARI MOGHADAM A., MAKHDOUMI KH., MAHDI ZADEH KHALIFANI A.R.. STUDY OF DIURETIC EFFECTS OF ALBUMIN & FUROSEMIDE CO-ADMINISTRATION COMPARED TO FUROSEMIDE IN PATIENTS WITH THE NEPHROTIC SYNDROME. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2007;18(1):422-426. Available from: https://sid.ir/paper/64395/en

IEEE: Copy

A. GHAFARI MOGHADAM, KH. MAKHDOUMI, and A.R. MAHDI ZADEH KHALIFANI, “STUDY OF DIURETIC EFFECTS OF ALBUMIN & FUROSEMIDE CO-ADMINISTRATION COMPARED TO FUROSEMIDE IN PATIENTS WITH THE NEPHROTIC SYNDROME,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 18, no. 1, pp. 422–426, 2007, [Online]. Available: https://sid.ir/paper/64395/en

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