PREVALENCE OF GNB3 C825T GENE POLYMORPHISM IN CHILDREN WITH VESICOURETERAL REFLUX IN KERMAN

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BAZRAFSHANI MOHAMMADREZA; PARVARESH SAEEDEH; NEZAMABADI POUR NAJMEH; HOSSEINI FATEMEH

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Journal: Journal of Kerman University of Medical Sciences Year:2015 | Volume:22 | Issue:1 Page(s): 12-20

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Title

PREVALENCE OF GNB3 C825T GENE POLYMORPHISM IN CHILDREN WITH VESICOURETERAL REFLUX IN KERMAN

Author(s)

BAZRAFSHANI MOHAMMADREZA | PARVARESH SAEEDEH | NEZAMABADI POUR NAJMEH | HOSSEINI FATEMEH | Issue Writer Certificate

Keywords

C825T POLYMORPHISMQ2

GNB3 GENEQ2

VESICOURETERAL REFLUXQ3

Abstract

Background & Aims: VESICOURETERAL REFLUX (VUR) is a congenital defect of the urinary tract which has been reported in approximately 1% of children. Several immunological and genetic factors are listed as major causes of this problem. The C825T POLYMORPHISM of the GNB3 GENE is among the genetic factors that may be involved in the development or progression of the disease. Participatory role of this polymorphism has been reported in several diseases, but its role in the development or progression of this disease is still not set correctly.Methods: This study, based on a Case-Control analysis, was carried out in Kerman province. A total of 80 children with VUR and 80 healthy children were selected and frequency of C825T POLYMORPHISM of the GNB3 GENE was examined by using PCR-RLFP.Results: The overall prevalence of heterozygous CT genotype of GNB3 GENE in patients with VUR was significantly higher compared to the control group (P=0.012, OR=1.92).Conclusion: These results suggest that the C825T POLYMORPHISM may be involved in establishing the initial VUR. However, further studies to determine the role of this gene as a marker for predicting the likelihood of VUR is required.

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APA: Copy

BAZRAFSHANI, MOHAMMADREZA, PARVARESH, SAEEDEH, NEZAMABADI POUR, NAJMEH, & HOSSEINI, FATEMEH. (2015). PREVALENCE OF GNB3 C825T GENE POLYMORPHISM IN CHILDREN WITH VESICOURETERAL REFLUX IN KERMAN. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 22(1), 12-20. SID. https://sid.ir/paper/646/en

Vancouver: Copy

BAZRAFSHANI MOHAMMADREZA, PARVARESH SAEEDEH, NEZAMABADI POUR NAJMEH, HOSSEINI FATEMEH. PREVALENCE OF GNB3 C825T GENE POLYMORPHISM IN CHILDREN WITH VESICOURETERAL REFLUX IN KERMAN. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;22(1):12-20. Available from: https://sid.ir/paper/646/en

IEEE: Copy

MOHAMMADREZA BAZRAFSHANI, SAEEDEH PARVARESH, NAJMEH NEZAMABADI POUR, and FATEMEH HOSSEINI, “PREVALENCE OF GNB3 C825T GENE POLYMORPHISM IN CHILDREN WITH VESICOURETERAL REFLUX IN KERMAN,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 1, pp. 12–20, 2015, [Online]. Available: https://sid.ir/paper/646/en

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