TIME-DEPENDENT EFFECT OF ENCAPSULATING ALGINATE HYDROGEL ON NEUROGENIC POTENTIAL

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RAZAVI SHAHNAZ; KHOSRAVIZADEH ZAHRA; BAHRAMIAN HAMID; KAZEMI MOHAMMAD

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Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2015 | Volume:17 | Issue:2 Page(s): 304-311

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Information Journal Paper

Title

TIME-DEPENDENT EFFECT OF ENCAPSULATING ALGINATE HYDROGEL ON NEUROGENIC POTENTIAL

Author(s)

RAZAVI SHAHNAZ | KHOSRAVIZADEH ZAHRA | BAHRAMIAN HAMID | KAZEMI MOHAMMAD | Issue Writer Certificate

Keywords

ALGINATE

MESENCHYMAL STEM CELLS

NEUROGENIC DIFFERENTIATION

PROLIFERATION

TISSUE ENGINEERING

Abstract

Objective: Due to the restricted potential of neural stem cells for regeneration of central nervous system (CNS) after injury, providing an alternative source for neural stem cells is essential. Adipose derived stem cells (ADSCs) are multipotent cells with properties suitable for TISSUE ENGINEERING. In addition, ALGINATE hydrogel is a biocompatible polysaccharide polymer that has been used to encapsulate many types of cells. The aim of this study was to assess the PROLIFERATION rate and level of expression of neural markers; NESTIN, glial fibrillary acidic protein (GFAP) and microtubule-associated protein 2 (MAP2) in encapsulated human ADSCs (hADSCs) 10 and14 days after neural induction.Materials and Methods: In this experimental study, ADSCs isolated from human were cultured in neural induction media and seeded into ALGINATE hydrogel. The rate of PROLIFERATION and differentiation of encapsulated cells were evaluated by 3- [4, 5-dimethylthiazol- 2-yl] -2, 5-diphenyl tetrazolium bromide (MTT) assay, immunocytoflourescent and real-time reverse transcriptase polymerase chain reaction (RT-PCR) analyzes 10 and 14 days after induction.Results: The rate of PROLIFERATION of encapsulated cells was not significantly changed with time passage. The expression of NESTIN and GFAP significantly decreased on day 14 relative to day 10 (P<0.001) but MAP2 expression was increased.Conclusion: ALGINATE hydrogel can promote the neural differentiation of encapsulated hADSCs with time passage.

Cites

THE APPLICATION OF ALGINATE SCAFFOLD IN NEURAL TISSUE ENGINEERING

References

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APA: Copy

RAZAVI, SHAHNAZ, KHOSRAVIZADEH, ZAHRA, BAHRAMIAN, HAMID, & KAZEMI, MOHAMMAD. (2015). TIME-DEPENDENT EFFECT OF ENCAPSULATING ALGINATE HYDROGEL ON NEUROGENIC POTENTIAL. CELL JOURNAL (YAKHTEH), 17(2), 304-311. SID. https://sid.ir/paper/647220/en

Vancouver: Copy

RAZAVI SHAHNAZ, KHOSRAVIZADEH ZAHRA, BAHRAMIAN HAMID, KAZEMI MOHAMMAD. TIME-DEPENDENT EFFECT OF ENCAPSULATING ALGINATE HYDROGEL ON NEUROGENIC POTENTIAL. CELL JOURNAL (YAKHTEH)[Internet]. 2015;17(2):304-311. Available from: https://sid.ir/paper/647220/en

IEEE: Copy

SHAHNAZ RAZAVI, ZAHRA KHOSRAVIZADEH, HAMID BAHRAMIAN, and MOHAMMAD KAZEMI, “TIME-DEPENDENT EFFECT OF ENCAPSULATING ALGINATE HYDROGEL ON NEUROGENIC POTENTIAL,” CELL JOURNAL (YAKHTEH), vol. 17, no. 2, pp. 304–311, 2015, [Online]. Available: https://sid.ir/paper/647220/en

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