TERATOGENIC EFFECTS OF THE ORAL TITANIUM DIOXIDE NP(TIO2) ON MORPHOLOGY AND SKELETAL STRUCTURE OF FETAL MICE NMRI IN DIFFERENT GESTATIONAL WEEKS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ABDI ARDESTANI MOHAMAD HASAN; ANVARI MORTEZA; SHAHEDI ABBAS; YADEGARI MARYAM; KHORADMEHR AREZOO; RASTAGHI SEDIGHEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Obstetrics, Gynecology and Infertility Year:2018 | Volume:20 | Issue:11 Page(s): 54-63

Download Full-Text

Persian Verion

View:

982

Download:

Cites:

Information Journal Paper

Title

TERATOGENIC EFFECTS OF THE ORAL TITANIUM DIOXIDE NP(TIO2) ON MORPHOLOGY AND SKELETAL STRUCTURE OF FETAL MICE NMRI IN DIFFERENT GESTATIONAL WEEKS

Author(s)

Keywords

NANOPARTICLESQ1

SKELETAL DISORDERSQ1

TERATOGENQ1

TITANIUMQ1

Abstract

Introduction: Considering the development of nanotechnology and extensive use of nano-materials are in different fields of industry, it is necessary to investigate their destructive effects on biological systems. TITANIUM dioxide (TiO2) is used in the production of different dyes, cosmetics, ceramics, photocatalysts, water and sewage treatment and a lot of other products. This study was performed with aim to evaluate the TERATOGENic effect of TiO2 in different gestational weeks of NMRI mice.Methods: This experimental study was performed on 30 female NMRI mice (25-30 gr, 8-12 weeks of pregnancy) in 2017. The mice were randomly assigned into 2 control groups and 4 case groups). Pregnancy was confirmed with vaginal plaque (GD0). The doses of 5 mg/kg of tio2 solution were orally gavage to pregnant mice from the first to 18th days of pregnancy. The first group, the first week of pregnancy, the second group, the second week of pregnancy and the third group received NANOPARTICLES only in the third week of pregnancy and the fourth case group were treated during all period of pregnancy. The Sham group was gavage with solvent and control group received city water without gavage. In the 18th day of pregnancy, the fetuses were removed from the uterine tubes and their weight and height, Head circumference and morphologic disorders were recorded, their SKELETAL DISORDERS were checked by alizarin red and painting. Data were analyzed by SPSS software (version 21). P<0.05 was considered significant.Results: Totally, significant reduction in body weight and CR length was observed in all four experimental groups in comparison with control group (P<0.05). Also, significant increasing was observed in appearance abnormalities such as fetal absorption, bleeding, organs abnormalities, and SKELETAL DISORDERS in experimental groups in comparison with control group. The observations showed more incidence of TERATOGENic effect in the group which was exposed to NANOPARTICLES in second week.Conclusion: The results of present study prove the toxicity and TERATOGENicity effects of TiO2 NANOPARTICLES on living organisms. So, further studies are recommended to predict the toxicity effect of TiO2.

Cites

No record.

References

No record.

Cite

APA: Copy

ABDI ARDESTANI, MOHAMAD HASAN, ANVARI, MORTEZA, SHAHEDI, ABBAS, YADEGARI, MARYAM, KHORADMEHR, AREZOO, & RASTAGHI, SEDIGHEH. (2018). TERATOGENIC EFFECTS OF THE ORAL TITANIUM DIOXIDE NP(TIO2) ON MORPHOLOGY AND SKELETAL STRUCTURE OF FETAL MICE NMRI IN DIFFERENT GESTATIONAL WEEKS. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, 20(11 ), 54-63. SID. https://sid.ir/paper/64936/en

Vancouver: Copy

ABDI ARDESTANI MOHAMAD HASAN, ANVARI MORTEZA, SHAHEDI ABBAS, YADEGARI MARYAM, KHORADMEHR AREZOO, RASTAGHI SEDIGHEH. TERATOGENIC EFFECTS OF THE ORAL TITANIUM DIOXIDE NP(TIO2) ON MORPHOLOGY AND SKELETAL STRUCTURE OF FETAL MICE NMRI IN DIFFERENT GESTATIONAL WEEKS. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY[Internet]. 2018;20(11 ):54-63. Available from: https://sid.ir/paper/64936/en

IEEE: Copy

MOHAMAD HASAN ABDI ARDESTANI, MORTEZA ANVARI, ABBAS SHAHEDI, MARYAM YADEGARI, AREZOO KHORADMEHR, and SEDIGHEH RASTAGHI, “TERATOGENIC EFFECTS OF THE ORAL TITANIUM DIOXIDE NP(TIO2) ON MORPHOLOGY AND SKELETAL STRUCTURE OF FETAL MICE NMRI IN DIFFERENT GESTATIONAL WEEKS,” IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, vol. 20, no. 11 , pp. 54–63, 2018, [Online]. Available: https://sid.ir/paper/64936/en

Related Journal Papers