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Information Journal Paper

Title

ATTENUATION OF CYCLOSPORINE-INDUCED SPERM IMPAIRMENT AND EMBRYOTOXICITY BY CRATAEGU'S MONOGYNA FRUIT AQUEOUS EXTRACT

Pages

  198-205

Abstract

 Objective: CYCLOSPORINE (Cs), a cyclic undecapeptide with potent immunosuppressive activity, causes several adverse effects including reproductive toxicity. This study aims to examine the ability of CRATAEGUS MONOGYNA aqueous fruit extract as an antioxidant to protect against Cs-induced reproductive toxicity.Materials and Methods: In this experimental study, 32 adult male Wistar rats were divided into four groups of eight animals each. Rats in two groups received 40 mg/kg/day Cs for 45 days by oral gavage. In addition, one of the two groups received CRATAEGUS MONOGYNA aqueous extract at a dose of 20 mg/kg/day orally four hours after Cs administration. The remaining two groups consisted of a vehicle treated control (Cont) group and a CRATAEGUS MONOGYNA control (Cr) group. Differences between groups were assessed by analysis of variance (ANOVA) using the SPSS software package for Windows.Results: Cs treatment caused a significant decrease in SPERM count and viability with an increase in DNA damage and protamine deficiency of the SPERM cells. We observed significant decreases in fertilization rate and embryonic development, in addition to an increased rate of embryo arrest in Cs-treated rats. CRATAEGUS MONOGYNA co-administration attenuated all Cs-induced negative changes in the above-mentioned parameters.Conclusion: Supplementation with CRATAEGUS MONOGYNA a queous fruit extract could be useful against reproductive toxicity during Cs treatment in a rat model.

Cites

References

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APA: Copy

ARMAND, ZAHRA, NAJAFI, GHOLAMREZA, FAROKHI, FARAH, & SHALIZAR JALALI, ALI. (2013). ATTENUATION OF CYCLOSPORINE-INDUCED SPERM IMPAIRMENT AND EMBRYOTOXICITY BY CRATAEGU'S MONOGYNA FRUIT AQUEOUS EXTRACT. CELL JOURNAL (YAKHTEH), 15(3 (59)), 198-205. SID. https://sid.ir/paper/651667/en

Vancouver: Copy

ARMAND ZAHRA, NAJAFI GHOLAMREZA, FAROKHI FARAH, SHALIZAR JALALI ALI. ATTENUATION OF CYCLOSPORINE-INDUCED SPERM IMPAIRMENT AND EMBRYOTOXICITY BY CRATAEGU'S MONOGYNA FRUIT AQUEOUS EXTRACT. CELL JOURNAL (YAKHTEH)[Internet]. 2013;15(3 (59)):198-205. Available from: https://sid.ir/paper/651667/en

IEEE: Copy

ZAHRA ARMAND, GHOLAMREZA NAJAFI, FARAH FAROKHI, and ALI SHALIZAR JALALI, “ATTENUATION OF CYCLOSPORINE-INDUCED SPERM IMPAIRMENT AND EMBRYOTOXICITY BY CRATAEGU'S MONOGYNA FRUIT AQUEOUS EXTRACT,” CELL JOURNAL (YAKHTEH), vol. 15, no. 3 (59), pp. 198–205, 2013, [Online]. Available: https://sid.ir/paper/651667/en

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