COMPARISON OF DIFFERENT METHODS OF CHEMOTHERAPY IN THE TREATMENT OF LOW RISK GESTATIONAL THROPHOBLASTIC DISEASE

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EFTEKHAR Z.; YARANDI F.; MOGHADDASI N.

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Journal: Iranian Journal of Obstetrics, Gynecology and Infertility Year:2001 | Volume:3 | Issue:5-6 Page(s): 51-56

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Title

COMPARISON OF DIFFERENT METHODS OF CHEMOTHERAPY IN THE TREATMENT OF LOW RISK GESTATIONAL THROPHOBLASTIC DISEASE

Author(s)

EFTEKHAR Z. | YARANDI F. | MOGHADDASI N. | Issue Writer Certificate

Keywords

METHOTREXATEQ4

ACTINOMYCINQ4

GESTATIONAL TROPHOBLASTIC DISEASEQ3

Abstract

Low risk GESTATIONAL TROPHOBLASTIC DISEASE (LRGTD) has a good prognosis with single-agent chemotherapy. The goal is to offer a safe, effective, inexpensive, inexpensive and convenient therapy for patients with LRGTD. Puls ACTINOMYCIN-D, Puls METHOTREXATE, 5-day ACTINOMYCIN and METHOTREXATE leucovorin were compared on 54 cases of LRGTD in Mirza Kocak Khan Hospital, through a longiudinal study.During 2.5 years study patients received puIs ACTINOMYCIN-D (n-19), puls MTX (n = 13), 5-day ACTINOMYCIN (n = 8), MTX leucovorin (n =15).66.7% (n = 34) achieved remission with first line chemotherapy; remission rate was 100%, and no recurrence was seen after one year of follow up.Primary response rate was 68.8% (n = 11) for puis ACTINOMYCIN, 61.5% (n = 8) for puls MTX, 57.5% (n = 4) for 5-dayActinomycinand 73.3% (n = 11) for MTX and leucovorin. These differences were not significant. The mean time to responses was different among the four groups, with a range of 66-78 days. But the differences were not statistically significant. The mean course of chemotherapy were twice in puls MTX (8.4 ± 1.8) compared with other groups (4.3 ± 1.5) which is significant (p = 0.0001).

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APA: Copy

EFTEKHAR, Z., YARANDI, F., & MOGHADDASI, N.. (2001). COMPARISON OF DIFFERENT METHODS OF CHEMOTHERAPY IN THE TREATMENT OF LOW RISK GESTATIONAL THROPHOBLASTIC DISEASE. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, 3(5-6), 51-56. SID. https://sid.ir/paper/65284/en

Vancouver: Copy

EFTEKHAR Z., YARANDI F., MOGHADDASI N.. COMPARISON OF DIFFERENT METHODS OF CHEMOTHERAPY IN THE TREATMENT OF LOW RISK GESTATIONAL THROPHOBLASTIC DISEASE. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY[Internet]. 2001;3(5-6):51-56. Available from: https://sid.ir/paper/65284/en

IEEE: Copy

Z. EFTEKHAR, F. YARANDI, and N. MOGHADDASI, “COMPARISON OF DIFFERENT METHODS OF CHEMOTHERAPY IN THE TREATMENT OF LOW RISK GESTATIONAL THROPHOBLASTIC DISEASE,” IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, vol. 3, no. 5-6, pp. 51–56, 2001, [Online]. Available: https://sid.ir/paper/65284/en

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