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Information Journal Paper

Title

THE PROTECTIVE EFFECT OF REGULAR AEROBIC TRAINING ON DOXORUBICIN-INDUCED HEPATOTOXICITY IN RATS: THE INSULIN-LIKE GROWTH FACTOR SYSTEM

Pages

  59-64

Abstract

 Background: The liver plays a central role in INSULIN-LIKE GROWTH FACTOR (IGF) system homeostasis. We examine the protective aerobic training on the IGF system following DOXORUBICIN (DOX) induced HEPATOTOXICITY.Materials and Methods: In this experimental study 48 Wistar male RATS (weighing 257±28 g) were divided into 6 groups: (1) control+placebo (2) control+DOX 10 mg/kg (3) control+DOX 20 mg/kg (4) training+placebo (5) training+DOX 10 mg/kg (6) training+DOX 20 mg/kg. HEPATOTOXICITY was induced by DOX (10 and 20 mg/kg). RATS in the 4, 5 and 6 groups performed treadmill running of 25 to 54 min/day and 15 to 20 m/min, 5 days/week for 3 weeks. Results: While, DOX 10 mg/kg administration result in an insignificant increase in IGF-1 and IGF-1/IGFBP-3 and an insignificant decrease in IGFBP-3, DOX 20 mg/kg administration caused a significant increase in IGF-1 and IGF-1/IGFBP-3, an insignificant decrease in IGFBP-3, as compared to the group 1. Three weeks of the endurance exercise resulted in a significant decrease of IGF-1 and IGF-1/IGFBP-3 levels, and significant increase in IGFBP-3, as compared to the group 1. Furthermore, after 3 weeks endurance training and DOX treatment with 10 mg/kg an insignificant decrease in IGF-1, an insignificant increase in IGFBP-3 and a significant decrease in IGF-1/IGFBP-3 were detected, in comparison to group 2.Conclusion: DOX HEPATOTOXICITY is dose-dependent, acute administration of DOX 20 mg/kg caused an imbalance in the IGF system and protective aerobic training may improve DOX-induced HEPATOTOXICITY by up-regulation of IGFBP3.

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    APA: Copy

    ALISHAHI, AILIN, & NASIRI, SARA. (2014). THE PROTECTIVE EFFECT OF REGULAR AEROBIC TRAINING ON DOXORUBICIN-INDUCED HEPATOTOXICITY IN RATS: THE INSULIN-LIKE GROWTH FACTOR SYSTEM. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 16(12), 59-64. SID. https://sid.ir/paper/664914/en

    Vancouver: Copy

    ALISHAHI AILIN, NASIRI SARA. THE PROTECTIVE EFFECT OF REGULAR AEROBIC TRAINING ON DOXORUBICIN-INDUCED HEPATOTOXICITY IN RATS: THE INSULIN-LIKE GROWTH FACTOR SYSTEM. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2014;16(12):59-64. Available from: https://sid.ir/paper/664914/en

    IEEE: Copy

    AILIN ALISHAHI, and SARA NASIRI, “THE PROTECTIVE EFFECT OF REGULAR AEROBIC TRAINING ON DOXORUBICIN-INDUCED HEPATOTOXICITY IN RATS: THE INSULIN-LIKE GROWTH FACTOR SYSTEM,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 16, no. 12, pp. 59–64, 2014, [Online]. Available: https://sid.ir/paper/664914/en

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