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Title

EARLY ADAPTATION OF SMALL INTESTINE AFTER MASSIVE SMALL BOWEL RESECTION IN RATS

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Abstract

 Background: It is important that the residual bowel adapts after massive resection. The necessary intestinal adaptation is a progressive recovery from intestinal failure through increase in absorptive surface area and functional capacity and includes both morphological and functional adaptations.Objectives: The aim of this study was to investigate intestinal morphological and functional adaptations of small bowel syndrome (SBS) model rats (SBS1W) 7 days after bowel resection.Materials and Methods: Male Sprague-dawley rats (n=20/group) underwent either a 75% proximal small bowel resection (SBS1W group) or a control operation (control group). Markers of morphological adaptation were revealed by TEM analysis of H&E-stained tissue samples. The intestinal barrier condition was assessed by BT, and sIgA concentration in intestinal mucus was measured by ELISA. Contractility and the slow wave rhythm of the entire intestinal remnant were measured and recorded.Results: The SBS1W group experienced more weight loss than control group and had a clearly different intestinal morphology as revealed in TEM images. Compared with control rats, the SBS1W group had a lower sIgA concentration in intestinal mucus and higher BT to lymph nodes (70% vs 40%; level I), portal blood (40% vs 10%; level II), and peripheral blood (60% vs 30%; level III). Disorder of spontaneous rhythmic contraction, irregular amplitude, and slow frequency were detected in the SBS1W group by a muscle strips test. Similarly, the slow wave of the entire intestinal remnant in the SBS1W group was irregular and uncoordinated.Conclusions: The finding of intestinal adaptation following massive SBR in SBS1W rats provides more understanding of the mechanisms of progressive recovery from the intestinal failure that underlies SBS. The mechanical, chemical, immunological, and biological barriers were all impaired at 7 days following bowel resection, indicating that the SBS model rats were still in the intestinal adaptation phase.

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    APA: Copy

    CHEN, JIE, QIN, ZHEN, SHAN, HONGMEI, XIAO, YONGTAO, & CAI, WEI. (2015). EARLY ADAPTATION OF SMALL INTESTINE AFTER MASSIVE SMALL BOWEL RESECTION IN RATS. IRANIAN JOURNAL OF PEDIATRICS, 25(4), 0-0. SID. https://sid.ir/paper/665156/en

    Vancouver: Copy

    CHEN JIE, QIN ZHEN, SHAN HONGMEI, XIAO YONGTAO, CAI WEI. EARLY ADAPTATION OF SMALL INTESTINE AFTER MASSIVE SMALL BOWEL RESECTION IN RATS. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2015;25(4):0-0. Available from: https://sid.ir/paper/665156/en

    IEEE: Copy

    JIE CHEN, ZHEN QIN, HONGMEI SHAN, YONGTAO XIAO, and WEI CAI, “EARLY ADAPTATION OF SMALL INTESTINE AFTER MASSIVE SMALL BOWEL RESECTION IN RATS,” IRANIAN JOURNAL OF PEDIATRICS, vol. 25, no. 4, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/665156/en

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