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Title

HIGH-DOSE ORAL IBUPROFEN IN TREATMENT OF PATENT DUCTUS ARTERIOSUS IN FULL-TERM NEONATES

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Abstract

 Background: Patent DUCTUS ARTERIOSUS (PDA) is an important risk for heart failure due to left to right shunt in TERM NEONATEs.Objectives: In this study, we evaluated the effect of high dose ibuprofen in closure of PDA in TERM NEONATEs.Patients and Methods: We used double dose ibuprofen (20 mg/kg, 10 mg/kg, and 10 mg/kg) for 3 - 30 day old TERM NEONATEs with PDA who were admitted in the neonatal wards of Shiraz University of Medical Sciences. The results of this study were compared to the data of the previous study in our center which used the low dose of ibuprofen (10 mg/kg, 5 mg/kg, and 5 mg/kg).Results: 29 full TERM NEONATEs received high-dose ibuprofen, in 18 neonates, PDA was closed after 4 days (62.1% versus 43.3% for the standard dose and 4.7% for the control group in the previous study) (P = 0.001). The results showed no significant correlation between the closure rate and gestational age, postnatal age, sex, and weight. In the 4th day of treatment, size of the pulmonic end of DUCTUS ARTERIOSUS decreased from 2.09 mm to 0.77 mm compared to 1.68 mm to 0.81 mm in the standard dose of oral ibuprofen and 2.1 mm to 1.4 mm in the control group (P=0.046).Conclusions: This study indicated that high-dose oral ibuprofen was more effective in closing or decreasing the size of PDA.

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    APA: Copy

    POURARIAN, SHAHNAZ, REZAIE, MEHRDAD, AMOOZGAR, HAMID, SHAKIBA, ALI MOHAMMAD, EDRAKI, MOHAMMAD REZA, & MEHDIZADEGAN, NIMA. (2015). HIGH-DOSE ORAL IBUPROFEN IN TREATMENT OF PATENT DUCTUS ARTERIOSUS IN FULL-TERM NEONATES. IRANIAN JOURNAL OF PEDIATRICS, 25(4), 0-0. SID. https://sid.ir/paper/665723/en

    Vancouver: Copy

    POURARIAN SHAHNAZ, REZAIE MEHRDAD, AMOOZGAR HAMID, SHAKIBA ALI MOHAMMAD, EDRAKI MOHAMMAD REZA, MEHDIZADEGAN NIMA. HIGH-DOSE ORAL IBUPROFEN IN TREATMENT OF PATENT DUCTUS ARTERIOSUS IN FULL-TERM NEONATES. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2015;25(4):0-0. Available from: https://sid.ir/paper/665723/en

    IEEE: Copy

    SHAHNAZ POURARIAN, MEHRDAD REZAIE, HAMID AMOOZGAR, ALI MOHAMMAD SHAKIBA, MOHAMMAD REZA EDRAKI, and NIMA MEHDIZADEGAN, “HIGH-DOSE ORAL IBUPROFEN IN TREATMENT OF PATENT DUCTUS ARTERIOSUS IN FULL-TERM NEONATES,” IRANIAN JOURNAL OF PEDIATRICS, vol. 25, no. 4, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/665723/en

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