DIAGNOSTIC ACCURACY OF PLEURAL FLUID TUMOR NECROSIS FACTOR-α IN TUBERCULOUS PLEURISY: A META-ANALYSIS

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LI ZHENZHEN; QIN WENZHE; LI LEI; WU QIN; CHEN XUERONG

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2015 | Volume:20 | Issue:7 Page(s): 702-707

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Title

DIAGNOSTIC ACCURACY OF PLEURAL FLUID TUMOR NECROSIS FACTOR-α IN TUBERCULOUS PLEURISY: A META-ANALYSIS

Author(s)

Keywords

DIAGNOSIS

META-ANALYSIS

TUBERCULOUS PLEURISY

TUMOR NECROSIS FACTOR-α

Abstract

Background: Pleurisy is a common extra pulmonary complication of tuberculosis, but current methods for diagnosing it are fairly crude. Here we product a META-ANALYSIS for the available evidence on the ability of tumor necrosis factor-a (TNF-a) in pleural fluid to serve as a diagnostic marker of TUBERCULOUS PLEURISY (TP).Materials and Methods: We searched the PubMed, EMBASE, and Google Scholar databases systematically for studies measuring sensitivity, specificity and other measures of diagnostic accuracy of pleural fluid TNF-a in the DIAGNOSIS of TP were meta-analyzed by Stata, version 12 and meta-disc.Results: A total of six publications reporting seven case-control studies were identified. Pooled results indicated that pleural fluid TNF-a showed a diagnostic sensitivity of 0.89 (95% confidence interval [95% CI] 0.83-0.93; range, 0.42-1.0) and a diagnostic specificity of 0.82 (95% CI: 0.78-0.86; range, 0.58-0.98). The pooled positive likelihood ratio was 4.78 (95% CI: 3.32-6.89); the negative likelihood ratio, 0.16 (95% CI: 0.1-0.27); the diagnostic odds ratio, 32.43 (95% CI: 14.48-72.6); and the area under the curve was 0.8556 (standard error of mean 0.0559).Conclusion: Pleural fluid TNF-a levels shows relatively high sensitivity but insufficient specificity for diagnosing TP. Pleural fluid TNF-a measurement may be useful in combination with clinical manifestations and conventional tests such as microbiological examination or pleural biopsy.

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APA: Copy

LI, ZHENZHEN, QIN, WENZHE, LI, LEI, WU, QIN, & CHEN, XUERONG. (2015). DIAGNOSTIC ACCURACY OF PLEURAL FLUID TUMOR NECROSIS FACTOR-α IN TUBERCULOUS PLEURISY: A META-ANALYSIS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 20(7), 702-707. SID. https://sid.ir/paper/667035/en

Vancouver: Copy

LI ZHENZHEN, QIN WENZHE, LI LEI, WU QIN, CHEN XUERONG. DIAGNOSTIC ACCURACY OF PLEURAL FLUID TUMOR NECROSIS FACTOR-α IN TUBERCULOUS PLEURISY: A META-ANALYSIS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2015;20(7):702-707. Available from: https://sid.ir/paper/667035/en

IEEE: Copy

ZHENZHEN LI, WENZHE QIN, LEI LI, QIN WU, and XUERONG CHEN, “DIAGNOSTIC ACCURACY OF PLEURAL FLUID TUMOR NECROSIS FACTOR-α IN TUBERCULOUS PLEURISY: A META-ANALYSIS,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 20, no. 7, pp. 702–707, 2015, [Online]. Available: https://sid.ir/paper/667035/en

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