مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

365
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

248
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

4

Information Journal Paper

Title

DOWN‐REGULATION OF MIR-135B IN COLON ADENOCARCINOMA INDUCED BY A TGF‐β RECEPTOR I KINASE INHIBITOR (SD-208)

Pages

  856-861

Keywords

MICRO RNAS (MIRNAS) 
TGF‐β RECEPTOR 1 (TGβRI) 

Abstract

 Objective (s): Transforming growth factor‐ b (TGF‐ b) is involved in colorectal cancer (CRC). The SD‐208 acts as an anti‐cancer agent in different malignancies via TGF‐ b signaling. This work aims to show the effect of manipulation of TGF‐Ò signaling on some miRNAs implicated in CRC.Materials and Methods: We investigated the effects of SD‐208 on SW‐48, a colon adenocarcinoma cell line. The cell line was treated with 0.5, 1 and 2 mM concentrations of SD‐208. Then, the xenograft model of COLON CANCER was established by subcutaneous inoculation of SW‐48 cell line into the nude mice. The animals were treated with SD‐208 for three weeks. A quantitative real‐time PCR was carried out for expression level analysis of selected oncogenic (miR‐21, 31, 20a and 135b) and suppressormiRNAs (let7‐g, miR‐133b, 145 and 200c). Data were analyzed using the 2‐DDCT method through student’s t‐test via the GraphPad Prism software.Results: Our results revealed that SD‐208 could significantly down‐regulate the expression of one key onco‐miRNA, miR‐135b, in either SW‐48 colon cells (P=0.006) or tumors orthotopically implanted in nude mice (P=0.018). Our in silico study also predicted that SD‐208 could modulate the expression of potential downstream tumor suppressor targets of the miR135b.Conclusion: Our data provide novel evidence that anticancer effects of SD‐208 (and likely other TGF‐ b inhibitors) may be owing to their ability to regulate miRNAs expression. Article history:

Cites

References

  • No record.

    • Cite

    APA: Copy

    AKBARI, ABOLFAZL, GHAHREMANI, MOHAMMAD HOSSEIN, MOBINI, GHOLAMREZA, ABASTABAR, MAHDI, AKHTARI, JAVAD, BOLHASSANI, MANZAR, & HEIDARI, MANSOUR. (2015). DOWN?REGULATION OF MIR-135B IN COLON ADENOCARCINOMA INDUCED BY A TGF?β RECEPTOR I KINASE INHIBITOR (SD-208). IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(9), 856-861. SID. https://sid.ir/paper/668246/en

    Vancouver: Copy

    AKBARI ABOLFAZL, GHAHREMANI MOHAMMAD HOSSEIN, MOBINI GHOLAMREZA, ABASTABAR MAHDI, AKHTARI JAVAD, BOLHASSANI MANZAR, HEIDARI MANSOUR. DOWN?REGULATION OF MIR-135B IN COLON ADENOCARCINOMA INDUCED BY A TGF?β RECEPTOR I KINASE INHIBITOR (SD-208). IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(9):856-861. Available from: https://sid.ir/paper/668246/en

    IEEE: Copy

    ABOLFAZL AKBARI, MOHAMMAD HOSSEIN GHAHREMANI, GHOLAMREZA MOBINI, MAHDI ABASTABAR, JAVAD AKHTARI, MANZAR BOLHASSANI, and MANSOUR HEIDARI, “DOWN?REGULATION OF MIR-135B IN COLON ADENOCARCINOMA INDUCED BY A TGF?β RECEPTOR I KINASE INHIBITOR (SD-208),” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 9, pp. 856–861, 2015, [Online]. Available: https://sid.ir/paper/668246/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button