NEPHROPROTECTIVE ACTIVITY OF MAMMEA AFRICANA STEM BARK AGAINST PARACETAMOL INDUCED KIDNEY INJURY

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OKOKON JUDE EFIOM; MICHAEL BAWO

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Journal Paper

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Journal: JOURNAL OF HERBAL DRUGS Year:2014 | Volume:5 | Issue:1 Page(s): 45-54

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Title

NEPHROPROTECTIVE ACTIVITY OF MAMMEA AFRICANA STEM BARK AGAINST PARACETAMOL INDUCED KIDNEY INJURY

Author(s)

OKOKON JUDE EFIOM | MICHAEL BAWO | Issue Writer Certificate

Keywords

MAMMEA AFRICANA

NEPHROPROTECTIVE

ANTIOXIDANT

KIDNEY

Abstract

Background & Aim: MAMMEA AFRICANA sabine (Guttiferae) stembark commonly used traditionally to treat various diseases and ailments was evaluated for NEPHROPROTECTIVE activity against paracetamol – induced KIDNEY injury in rats to confirm its use in the treatment of KIDNEY diseases.Experimental: The NEPHROPROTECTIVE effect of the extract was evaluated by the determination of some KIDNEY function parameters such as serum urea and creatinine, electrolyes (K+, Na+, Cl- and HCO-3), ANTIOXIDANT enzymes (superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), malondialdehyde (MDA) and histopathological study of the liver.Results & Discussion: The administration of the stembark extract caused significant dose-dependent reduction of high levels of serum creatinine and urea. The electrolytes levels were not affected. Histology of the KIDNEY sections of extract and silymarin- treated animals showed reductions in the pathological features compared to the paracetamol- treated animals. The chemical pathological changes were consistent with histopathological observations suggesting marked NEPHROPROTECTIVE effect of the stembark extract of M. AfricanaRecommended applications/industries: The results show that the stembark extract of MAMMEA AFRICANA has NEPHROPROTECTIVE potential which may be due to its ANTIOXIDANT effect activity.

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APA: Copy

OKOKON, JUDE EFIOM, & MICHAEL, BAWO. (2014). NEPHROPROTECTIVE ACTIVITY OF MAMMEA AFRICANA STEM BARK AGAINST PARACETAMOL INDUCED KIDNEY INJURY. JOURNAL OF HERBAL DRUGS, 5(1), 45-54. SID. https://sid.ir/paper/674289/en

Vancouver: Copy

OKOKON JUDE EFIOM, MICHAEL BAWO. NEPHROPROTECTIVE ACTIVITY OF MAMMEA AFRICANA STEM BARK AGAINST PARACETAMOL INDUCED KIDNEY INJURY. JOURNAL OF HERBAL DRUGS[Internet]. 2014;5(1):45-54. Available from: https://sid.ir/paper/674289/en

IEEE: Copy

JUDE EFIOM OKOKON, and BAWO MICHAEL, “NEPHROPROTECTIVE ACTIVITY OF MAMMEA AFRICANA STEM BARK AGAINST PARACETAMOL INDUCED KIDNEY INJURY,” JOURNAL OF HERBAL DRUGS, vol. 5, no. 1, pp. 45–54, 2014, [Online]. Available: https://sid.ir/paper/674289/en

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