EFFECT OF THE ESSENTIAL OIL OF THYME ON INTESTINAL MORPHOLOGY IN RAT

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SEPEHRI MOGHADAM HESHMAT; EMADI MOZHDEH; MOLASHAHI ELHAM

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Journal Paper

Paper Information

Journal: JOURNAL OF HERBAL DRUGS Year:2014 | Volume:5 | Issue:1 Page(s): 39-43

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Title

EFFECT OF THE ESSENTIAL OIL OF THYME ON INTESTINAL MORPHOLOGY IN RAT

Author(s)

SEPEHRI MOGHADAM HESHMAT | EMADI MOZHDEH | MOLASHAHI ELHAM | Issue Writer Certificate

Keywords

INDOMETHACIN

SMALL INTESTINE

THYMUS VUGLARIS

VOLATILE OIL

Abstract

Background & Aim: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in clinical medicine. The adverse effects they produce in the gastrointestinal tract however, often limit their utility. Oxidative stress has been shown to occur in the SMALL INTESTINE in response to the oral administration of INDOMETHACIN. In view of this, the effect of thyme essential oil, an agent with anti-oxidant properties, was evaluated on INDOMETHACIN-induced small intestinal damage in a rat model.Experimental: The chemical composition of thyme essential oil was identified by gas chromatography mass spectrometry. Tissues morphology affected by INDOMETHACIN, with and without treatment with thyme, was measured.Results & Discussion: The SMALL INTESTINE morphology (villus height, villus width, and crypt depth and crypt width of duodenum, jejunum and ilea) from INDOMETHACIN-treated animals with thyme oil was significantly improved than those from INDOMETHACIN animals. Treatment with thyme oil was found to ameliorate these drug-induced changes.Recommended applications/industries: The essential oil of thyme appears to hold promise as an agent that can potentially reduce non-steroidal anti-inflammatory drugs induced small intestinal damage.

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APA: Copy

SEPEHRI MOGHADAM, HESHMAT, EMADI, MOZHDEH, & MOLASHAHI, ELHAM. (2014). EFFECT OF THE ESSENTIAL OIL OF THYME ON INTESTINAL MORPHOLOGY IN RAT. JOURNAL OF HERBAL DRUGS, 5(1), 39-43. SID. https://sid.ir/paper/676873/en

Vancouver: Copy

SEPEHRI MOGHADAM HESHMAT, EMADI MOZHDEH, MOLASHAHI ELHAM. EFFECT OF THE ESSENTIAL OIL OF THYME ON INTESTINAL MORPHOLOGY IN RAT. JOURNAL OF HERBAL DRUGS[Internet]. 2014;5(1):39-43. Available from: https://sid.ir/paper/676873/en

IEEE: Copy

HESHMAT SEPEHRI MOGHADAM, MOZHDEH EMADI, and ELHAM MOLASHAHI, “EFFECT OF THE ESSENTIAL OIL OF THYME ON INTESTINAL MORPHOLOGY IN RAT,” JOURNAL OF HERBAL DRUGS, vol. 5, no. 1, pp. 39–43, 2014, [Online]. Available: https://sid.ir/paper/676873/en

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