Effect of N-Acetylcysteine on hsCRP in Patients on Continues Ambulatory Peritoneal Dialysis: A Quasi-Experimental Study

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NAJAFI FARZANEH; Mousavi Roknabadi Razieh Sadat; PIRDEHGHAN AZAR; Rahimian Masoud; Nourimajalan Nader

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Journal: Nephro-Urology Monthly Year:2021 | Volume:13 | Issue:3 Page(s): 0-0

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Title

Effect of N-Acetylcysteine on hsCRP in Patients on Continues Ambulatory Peritoneal Dialysis: A Quasi-Experimental Study

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Keywords

C-reactive Protein

N-Acetylcysteine

Peritoneal Dialysis

End-Stage Renal Disease

Abstract

Background: Inflammatory processes are proved in patients with chronic kidney disease (CKD) as one of the leading causes of mortality and morbidity. N-Acetylcysteine (NAC) is known as an antioxidant drug with anti-inflammatory effects. Objectives: This study aimed to evaluate the effects of NAC on hsCRP in CKD patients on Peritoneal Dialysis. Methods: This quasi-experimental self-controlled study examined adult CKD patients on Peritoneal Dialysis referred to the Peritoneal Dialysis clinic. The participants were assigned into two groups (A: CRP of 5-15 mg/L and B: CRP < 5 mg/L), and both groups were treated with oral NAC 600mg twice a day for eight weeks. First, the hsCRP was measured before and after the intervention, and then all the collected data were analyzed. Results: Forty patients (n = 24 in the group A and n = 26 in the group B) participated in this study. NAC decreased the hsCRP level in both groups (P = 0. 001 in the group A vs. P = 0. 002 in group B); however, the decrease was more prominent in the group A (P = 0. 013). The hsCRP decrease was more significant in women (P = 0. 002) in general and women in the group B (P = 0. 02) in particular. The hsCRP variation had a significant relationship with the underlying disease (P = 0. 009). There was no significant correlation between the hsCRP variation with age (r =-0. 173, P = 0. 285) and the duration of dialysis. Conclusions: The administration of NAC (600 mg, twice a day for eight weeks) significantly decreased the level of hsCRP in patients on Peritoneal Dialysis, especially in those with CRP = 5-15 mh/L. The decrease has no relationship with age and duration of dialysis; however, it was more highlighted in women.

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APA: Copy

NAJAFI, FARZANEH, Rahimian, Masoud, & Nourimajalan, Nader. (2021). Effect of N-Acetylcysteine on hsCRP in Patients on Continues Ambulatory Peritoneal Dialysis: A Quasi-Experimental Study. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, 13(3), 0-0. SID. https://sid.ir/paper/681449/en

Vancouver: Copy

NAJAFI FARZANEH, Rahimian Masoud, Nourimajalan Nader. Effect of N-Acetylcysteine on hsCRP in Patients on Continues Ambulatory Peritoneal Dialysis: A Quasi-Experimental Study. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY[Internet]. 2021;13(3):0-0. Available from: https://sid.ir/paper/681449/en

IEEE: Copy

FARZANEH NAJAFI, Masoud Rahimian, and Nader Nourimajalan, “Effect of N-Acetylcysteine on hsCRP in Patients on Continues Ambulatory Peritoneal Dialysis: A Quasi-Experimental Study,” THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, vol. 13, no. 3, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/681449/en

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