مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

279
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

161
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

NONSENSE-MEDIATED MRNA DECAY AMONG COAGULATION FACTOR GENES

Pages

  344-349

Abstract

 Objective(s): Haemostasis prevents blood loss following vascular injury. It depends on the unique concert of events involving platelets and specific blood proteins, known as COAGULATION FACTORS. The clotting system requires precise regulation and coordinated reactions to maintain the integrity of the vasculature. Clotting insufficiency mostly occurs due to genetically inherited coagulation factor deficiencies such as hemophilia.Materials and Methods: A relevant literature search of PubMed was performed using the keywords COAGULATION FACTORS, Nonsense-mediated mRNA decay and premature translation termination codons. Search limitations included English language and human-based studies.Results: Mutations that cause premature translation termination codons probably account for one-third of genetically inherited diseases. Transcripts bearing aberrant termination codons are selectively identified and eliminated by an evolutionarily conserved posttranscriptional pathway known as nonsense-mediated mRNA decay (NMD). There are many pieces of evidence of decay among coagulation factor genes. However, the hemophilia gene (F8) does not seem to be subjected to NMD. Since the F8 gene is located on the X-chromosome, a connection between X-linked traits and mRNA decay could be assumed.Conclusion: Considering that not all genes go through decay, this review focuses on the basics of the mechanism in coagulation genes. It is interesting to determine whether this translation-coupled surveillance system represents a general rule for the genes encoding components of the same physiological cascade.

Cites

References

  • No record.

    • Cite

    APA: Copy

    SHAHBAZI, SHIRIN. (2016). NONSENSE-MEDIATED MRNA DECAY AMONG COAGULATION FACTOR GENES. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(4), 344-349. SID. https://sid.ir/paper/683326/en

    Vancouver: Copy

    SHAHBAZI SHIRIN. NONSENSE-MEDIATED MRNA DECAY AMONG COAGULATION FACTOR GENES. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(4):344-349. Available from: https://sid.ir/paper/683326/en

    IEEE: Copy

    SHIRIN SHAHBAZI, “NONSENSE-MEDIATED MRNA DECAY AMONG COAGULATION FACTOR GENES,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 4, pp. 344–349, 2016, [Online]. Available: https://sid.ir/paper/683326/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button