LETTER TO EDITOR: LOW PH PRECONDITIONED AMNIOTIC EPITHELIAL CELLS FOR STEM CELL THERAPY OF CANCER

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NIKNEJAD HASSAN; YAZDANPANAH GHASEM; KAKAVAND MONA; LAVAIE YASAMAN

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Journal: Physiology and Pharmacology Year:2016 | Volume:20 | Issue:1 Page(s): 1-4

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Title

LETTER TO EDITOR: LOW PH PRECONDITIONED AMNIOTIC EPITHELIAL CELLS FOR STEM CELL THERAPY OF CANCER

Author(s)

NIKNEJAD HASSAN | YAZDANPANAH GHASEM | KAKAVAND MONA | LAVAIE YASAMAN | Issue Writer Certificate

Keywords

AMNIOTIC MEMBRANE

EPITHELIAL CELLS

PRECONDITIONING

CANCER

STEM CELL THERAPY

Abstract

Amniotic EPITHELIAL CELLS (AECs) possess unique characteristics, which make them a suitable source for cell-based therapeutic strategies. AECs have stem cell properties with low-immunogenicity (due to expressing HLA-G molecule and absence of MHC class I and II antigens) and no ethical problems, as well as availability in sufficient numbers, which can be obtained from a placenta. We have recently shown that the AECs have anti-cancer properties due to inhibition of angiogenesis, induction of apoptosis and cell cycle arrest probably through inhibition of HSP90. Since the viability of AECs must be improved after in vivo administration in acidic microenvironment of tumor, we clarify here that low pH PRECONDITIONING of AECs would lead to more survival of implanted cells in tumor site as well as improved functional outcomes.

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References

EVALUATION OF CYTOTOXIC EFFECTS OF CONDITION MEDIUM FROM AMNIOTIC EPITHELIAL CELLS ON CANCER CELL LINES HELA AND MDA-MB-231

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APA: Copy

NIKNEJAD, HASSAN, YAZDANPANAH, GHASEM, KAKAVAND, MONA, & LAVAIE, YASAMAN. (2016). LETTER TO EDITOR: LOW PH PRECONDITIONED AMNIOTIC EPITHELIAL CELLS FOR STEM CELL THERAPY OF CANCER. PHYSIOLOGY AND PHARMACOLOGY, 20(1), 1-4. SID. https://sid.ir/paper/683569/en

Vancouver: Copy

NIKNEJAD HASSAN, YAZDANPANAH GHASEM, KAKAVAND MONA, LAVAIE YASAMAN. LETTER TO EDITOR: LOW PH PRECONDITIONED AMNIOTIC EPITHELIAL CELLS FOR STEM CELL THERAPY OF CANCER. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2016;20(1):1-4. Available from: https://sid.ir/paper/683569/en

IEEE: Copy

HASSAN NIKNEJAD, GHASEM YAZDANPANAH, MONA KAKAVAND, and YASAMAN LAVAIE, “LETTER TO EDITOR: LOW PH PRECONDITIONED AMNIOTIC EPITHELIAL CELLS FOR STEM CELL THERAPY OF CANCER,” PHYSIOLOGY AND PHARMACOLOGY, vol. 20, no. 1, pp. 1–4, 2016, [Online]. Available: https://sid.ir/paper/683569/en

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