مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

1,685
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

0
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

3

Information Journal Paper

Title

INVESTIGATION OF ANTINOCICEPTIVE AND ANTI-INFLAMMATORY EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF SECURIGERA SECURIDACA L.

Pages

  12-19

Abstract

 Background and Aim: The application of herbal plants instead of synthetic drugs is increasing in recent years because of their lower side-effects and high varieties of efficient components. The study of anti-inflammatory and antinociceptive effects of hydroalcoholic extract of Securigera securidaca L. seems to be necessary due to the existence of its anti-inflammatory and antinociceptive components.Materials and Methods: This study has been done on 156 NMRI MALE MICE of 20-25 g in weight. After determining LETHAL DOSE (LD50) of the extract, we used Xylene-induced ear edema and Formalin Test for demonstrating its anti-inflammatory and antinociceptive effects. In each of these two tests, the animals were divided into 6 groups (each group consisting of 8 mice): Sham, Positive Control (receiving dexamethasone at dose of 15 mg/kg in inflammatory test, and receiving morphine at dose of 10 mg/kg in formalin test), experimental groups receiving hydroalchoholic extract at doses of 42, 85, 170 and 340 mg/kg.Results: LD50 was obtained 1.7 gr/kg. This study shows that the SEED OF SECURIGERA SECURIDACA L. has anti-inflammatory effect at all doses, particularly at dose of 340 mg/kg. In addition, the extract decreased nociception meaningfully in both acute and chronic phases. Dose of 340 mg/kg had the most antinociceptive effect especially in chronic phase.Conclusion: The hydroalcoholic extract of Securigera securidaca L. has antinociceptive and anti-inflammatory effect in both phases (especially inflammatory phase) which is caused by formalin, and this effect may be flavonoid and tannin components in plants, which have ANTI-INFLAMMATION and antinociceptive properties. Flavonoid and tannin components in this plant may be the reason of these effects.

Cites

References

  • No record.

    • Cite

    APA: Copy

    HOODGAR, F., NASRI, S., & AMIN, GH.R.. (2011). INVESTIGATION OF ANTINOCICEPTIVE AND ANTI-INFLAMMATORY EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF SECURIGERA SECURIDACA L.. OFOGH-E-DANESH, 17(2 (51)), 12-19. SID. https://sid.ir/paper/68422/en

    Vancouver: Copy

    HOODGAR F., NASRI S., AMIN GH.R.. INVESTIGATION OF ANTINOCICEPTIVE AND ANTI-INFLAMMATORY EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF SECURIGERA SECURIDACA L.. OFOGH-E-DANESH[Internet]. 2011;17(2 (51)):12-19. Available from: https://sid.ir/paper/68422/en

    IEEE: Copy

    F. HOODGAR, S. NASRI, and GH.R. AMIN, “INVESTIGATION OF ANTINOCICEPTIVE AND ANTI-INFLAMMATORY EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF SECURIGERA SECURIDACA L.,” OFOGH-E-DANESH, vol. 17, no. 2 (51), pp. 12–19, 2011, [Online]. Available: https://sid.ir/paper/68422/en

    Related Journal Papers

    Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top