ANTI-PROLIFERATIVE AND APOPTOTIC EFFECTS OF BETA-IONONE IN HUMAN LEUKEMIA CELL LINE K562

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FAEZIZADEH ZOHREH; GHARIB AMIR; GOUDARZI MASOUD

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Journal: Zahedan Journal of Research in Medical Sciences Year:2016 | Volume:18 | Issue:6 Page(s): 0-0

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Title

ANTI-PROLIFERATIVE AND APOPTOTIC EFFECTS OF BETA-IONONE IN HUMAN LEUKEMIA CELL LINE K562

Author(s)

FAEZIZADEH ZOHREH | GHARIB AMIR | GOUDARZI MASOUD | Issue Writer Certificate

Keywords

BETA-IONONE

K562 CELL LINE

MTT ASSAY

APOPTOSIS

Abstract

Background: BETA-IONONE is an aroma compound found in the Rosaceae family. Some evidence supported that BETA-IONONE has a great potential for cancer prevention. To date, the anti-proliferative and apoptotic effects of BETA-IONONE in human leukemia cell line K562 were not studied.Objectives: Hence, we investigated whether BETA-IONONE could inhibit cell growth and induce APOPTOSIS in the K562 cells.Materials and Methods: In this experimental study, human leukemia cell line K562 was cultured and anti-proliferation effect of BETA-IONONE with different doses (25 - 400 mm) at different times (24 - 96 hours) on treated cells was evaluated by the MTT ASSAY. To determine APOPTOSIS rate, the Hoechst 33342 staining and flow cytometry was performed.Results: The MTT ASSAY showed that BETA-IONONE inhibited proliferation of K562 cells in a dose-dependent manner significantly (P= 0.0008). Moreover, the increased apoptotic rate was found after incubation of K562 cells with 200mm BETA-IONONE. The Hoechst staining and flow cytometry analysis indicated that BETA-IONONE could increase APOPTOSIS of K562 cells in a dose-dependent manner.Conclusions: The results demonstrated that BETA-IONONE has anti-proliferative and apoptotic effects on K562 cells, and in the future may be used in the treatment of some leukemia sub-types.

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APA: Copy

FAEZIZADEH, ZOHREH, GHARIB, AMIR, & GOUDARZI, MASOUD. (2016). ANTI-PROLIFERATIVE AND APOPTOTIC EFFECTS OF BETA-IONONE IN HUMAN LEUKEMIA CELL LINE K562. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 18(6), 0-0. SID. https://sid.ir/paper/684451/en

Vancouver: Copy

FAEZIZADEH ZOHREH, GHARIB AMIR, GOUDARZI MASOUD. ANTI-PROLIFERATIVE AND APOPTOTIC EFFECTS OF BETA-IONONE IN HUMAN LEUKEMIA CELL LINE K562. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2016;18(6):0-0. Available from: https://sid.ir/paper/684451/en

IEEE: Copy

ZOHREH FAEZIZADEH, AMIR GHARIB, and MASOUD GOUDARZI, “ANTI-PROLIFERATIVE AND APOPTOTIC EFFECTS OF BETA-IONONE IN HUMAN LEUKEMIA CELL LINE K562,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 18, no. 6, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/684451/en

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