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Information Journal Paper

Title

THE PROTECTIVE EFFECTS OF CURCUMA LONGA EXTRACT ON OXIDATIVE STRESS MARKERS IN THE LIVER INDUCED BY ADRIAMYCIN IN RATS

Pages

  31-37

Abstract

 Introduction: The aim of the study was to investigate the effects of CURCUMA LONGA (C. longa) extract on ADRIAMYCIN-induced HEPATOTOXICITY in RAT.Methods: Animals were divided in six groups: Control (CO), ADRIAMYCIN (ADR), ADRIAMYCIN with Vitamin C (ADR+VitC), Vitamin C (Vit C), C. longa with ADRIAMYCIN (CL+ADR) and without ADRIAMYCIN (CL-ADR). HEPATOTOXICITY was induced by ADRIAMYCIN 5mg/kg and RATs were treated withC. longa 1000 mg/kg and Vitamin C 100 mg/kg, per day, orally for 4 weeks.Results: In the liver tissue of ADR group, Malonyldialdehyde (MDA) level was increased significantly compared to CO group, (p<0.05). MDA level in the treatment groups, Vit C, CL+ADR and CL-ADR were increased significantly compared to ADR group (p<0.05, for all three groups), and compared to ADR+VitC group (p<0.01). Thiol level in ADR, ADR+VitC and CL+ADR groups were decreased compared to CO group (p<0.001), and also thiol level in CL-ADR and Vit C were increased significantly compared to ADR group (p<0.01 and p<0.001 respectively). The activity of catalase in liver tissue in ADR group was lower compared to CO group (p<0.01), though was increased in CL-ADR, ADR+VitC and Vit C groups in comparison with ADR group (p<0.05, p<0.01 and p<0.001, respectively).Conclusion: The results showed that chronic administration of C. longa HYDROALCOHOLIC EXTRACT in ADRIAMYCIN-induced hepatotoxic RATs could decrease the OXIDATIVE STRESS injuries in the liver tissue.

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    Cite

    APA: Copy

    KHAZDAIR, MOHAMMAD REZA, MOHEBBATI, REZA, KARIMI, SAREH, ABBASNEZHAD, ABBASALI, & HAGHSHENAS, MILAD. (2016). THE PROTECTIVE EFFECTS OF CURCUMA LONGA EXTRACT ON OXIDATIVE STRESS MARKERS IN THE LIVER INDUCED BY ADRIAMYCIN IN RATS. PHYSIOLOGY AND PHARMACOLOGY, 20(1), 31-37. SID. https://sid.ir/paper/685227/en

    Vancouver: Copy

    KHAZDAIR MOHAMMAD REZA, MOHEBBATI REZA, KARIMI SAREH, ABBASNEZHAD ABBASALI, HAGHSHENAS MILAD. THE PROTECTIVE EFFECTS OF CURCUMA LONGA EXTRACT ON OXIDATIVE STRESS MARKERS IN THE LIVER INDUCED BY ADRIAMYCIN IN RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2016;20(1):31-37. Available from: https://sid.ir/paper/685227/en

    IEEE: Copy

    MOHAMMAD REZA KHAZDAIR, REZA MOHEBBATI, SAREH KARIMI, ABBASALI ABBASNEZHAD, and MILAD HAGHSHENAS, “THE PROTECTIVE EFFECTS OF CURCUMA LONGA EXTRACT ON OXIDATIVE STRESS MARKERS IN THE LIVER INDUCED BY ADRIAMYCIN IN RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 20, no. 1, pp. 31–37, 2016, [Online]. Available: https://sid.ir/paper/685227/en

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