RELATION BETWEEN E-CADHERIN EXPRESSIONS IN PAPILLARY THYROID CARCINOMA WITH SOME PROGNOSTIC FACTORS

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JALALI NADOUSHAN M.R.; DAVATI A.; HASSANPOUR M.

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Journal: Internal Medicine Today Year:2014 | Volume:19 | Issue:4 Page(s): 192-196

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Title

RELATION BETWEEN E-CADHERIN EXPRESSIONS IN PAPILLARY THYROID CARCINOMA WITH SOME PROGNOSTIC FACTORS

Author(s)

JALALI NADOUSHAN M.R. | DAVATI A. | HASSANPOUR M. | Issue Writer Certificate

Keywords

PROGNOSISQ3

CADHERINZQ2

PAPILLARY CARCINOMA THYROIDQ1

Abstract

Aims: Thyroid cancer is the most common endocrine malignancy; and papillary carcinoma is the most common thyroid cancer. There are different biologic markers which are used for PROGNOSIS determination one of which is a cell binding molecule, E-cadherin. The purpose of this study was to determine the frequency of E-cadherin expression in papillary thyroid cancer and its relation with gender, tumor size, and lymph nodes involvement.Methods: This study was performed on 73 tissue samples from patients with papillary thyroid cancer who referred to Mostafa Khomeini Hospital in Tehran, Iran (2005- 2008). The method of staining for determination of E-cadherin expression was immunohistochemistry. We evaluated the size of tumor, lymph nodes involvement, and their relation with E-cadherin expression.Results: The mean age was 41.85±16.65 years. 67% of samples were positive for E-cadherin and 21.9% had lymph nodes involvement. The mean size of patients’ tumor was 3.86±2.38 cm. There was not any significant relationship between E-cadherin expression and tumor size and gender but there was a significant and reverse relationship between E-cadherin expression and lymph nodes involvement (P<0.05).Conclusion: Concerning of the role of the E-cadherin in patient PROGNOSIS, it seems that as proportion of E-cadherin decreases in tumor cells, the probability of lymph nodes involvement increases. More studies in this area with patients’ follow-up are recommended.

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APA: Copy

JALALI NADOUSHAN, M.R., DAVATI, A., & HASSANPOUR, M.. (2014). RELATION BETWEEN E-CADHERIN EXPRESSIONS IN PAPILLARY THYROID CARCINOMA WITH SOME PROGNOSTIC FACTORS. OFOGH-E-DANESH, 19(4), 192-196. SID. https://sid.ir/paper/68525/en

Vancouver: Copy

JALALI NADOUSHAN M.R., DAVATI A., HASSANPOUR M.. RELATION BETWEEN E-CADHERIN EXPRESSIONS IN PAPILLARY THYROID CARCINOMA WITH SOME PROGNOSTIC FACTORS. OFOGH-E-DANESH[Internet]. 2014;19(4):192-196. Available from: https://sid.ir/paper/68525/en

IEEE: Copy

M.R. JALALI NADOUSHAN, A. DAVATI, and M. HASSANPOUR, “RELATION BETWEEN E-CADHERIN EXPRESSIONS IN PAPILLARY THYROID CARCINOMA WITH SOME PROGNOSTIC FACTORS,” OFOGH-E-DANESH, vol. 19, no. 4, pp. 192–196, 2014, [Online]. Available: https://sid.ir/paper/68525/en

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