MESENCHYMAL STROMAL CELLS IMPLANTATION IN COMBINATION WITH PLATELET LYSATE PRODUCT IS SAFE FOR RECONSTRUCTION OF HUMAN LONG BONE NONUNION

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LABIBZADEH NARGES; EMADEDIN MOHSEN; FAZELI ROGHAYEH; MOHSENI FATEMEH; HOSSEINI SEYYEDEH ESMAT; MOGHADASALI REZA; MARDPOUR SOURA; AZIMIAN VAJIHEH; GHORBANI LIASTANI MAEDE; MIRAZIMI BAFGHI ALI; BAGHABAN ESLAMINEJAD MOHAMADREZA; AGHDAMI NASSER

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Journal: CELL JOURNAL (YAKHTEH) Year:2016 | Volume:18 | Issue:3 (71) Page(s): 302-309

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Title

MESENCHYMAL STROMAL CELLS IMPLANTATION IN COMBINATION WITH PLATELET LYSATE PRODUCT IS SAFE FOR RECONSTRUCTION OF HUMAN LONG BONE NONUNION

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Keywords

FRACTURES UNUNITED

MESENCHYMAL STROMAL CELLS

PLATELET LYSATE

Abstract

Objective: Nonunion is defined as a minimum of 9 months since injury without any visible progressive signs of healing for 3 months. Recent literature has shown that the application of mesenchymal stromal cells is safe, in vitro and in vivo, for treating long bone nonunion. The present study was performed to investigate the safety of mesenchymal stromal cell (MSC) implantation in combination with platelet lysate (PL) product for treating human long bone nonunion.Materials and Methods: In this case series clinical trial, orthopedic surgeons visited eighteen patients with long bone nonunion, of whom 7 complied with the eligibility criteria.These patients received mesenchymal stromal cells (20 million cells implanted once into the nonunion site using a fluoroscopic guide) in combination with PL product. For evaluation of the effects of this intervention all the patients were followed up by taking anterior-posterior and lateral X-rays of the affected limb before and 1, 3, 6, and 12 months after the implantation. All side effects (local or systemic, serious or non-serious, related or unrelated) were observed during this time period.Results: From a safety perspective the MSC implantation in combination with PL was very well tolerated during the 12 months of the trial. Four patients were healed; based on the control X- ray evidence, bony union had occurred.Conclusion: Results from the present study suggest that the implantation of bone marrow- derived MSCs in combination with PL is safe for the treatment of nonunion. A double blind, controlled clinical trial is required to assess the efficacy of this treatment (Registration Number: NCT01206179).

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APA: Copy

LABIBZADEH, NARGES, EMADEDIN, MOHSEN, FAZELI, ROGHAYEH, MOHSENI, FATEMEH, HOSSEINI, SEYYEDEH ESMAT, MOGHADASALI, REZA, MARDPOUR, SOURA, AZIMIAN, VAJIHEH, GHORBANI LIASTANI, MAEDE, MIRAZIMI BAFGHI, ALI, BAGHABAN ESLAMINEJAD, MOHAMADREZA, & AGHDAMI, NASSER. (2016). MESENCHYMAL STROMAL CELLS IMPLANTATION IN COMBINATION WITH PLATELET LYSATE PRODUCT IS SAFE FOR RECONSTRUCTION OF HUMAN LONG BONE NONUNION. CELL JOURNAL (YAKHTEH), 18(3 (71)), 302-309. SID. https://sid.ir/paper/685297/en

Vancouver: Copy

LABIBZADEH NARGES, EMADEDIN MOHSEN, FAZELI ROGHAYEH, MOHSENI FATEMEH, HOSSEINI SEYYEDEH ESMAT, MOGHADASALI REZA, MARDPOUR SOURA, AZIMIAN VAJIHEH, GHORBANI LIASTANI MAEDE, MIRAZIMI BAFGHI ALI, BAGHABAN ESLAMINEJAD MOHAMADREZA, AGHDAMI NASSER. MESENCHYMAL STROMAL CELLS IMPLANTATION IN COMBINATION WITH PLATELET LYSATE PRODUCT IS SAFE FOR RECONSTRUCTION OF HUMAN LONG BONE NONUNION. CELL JOURNAL (YAKHTEH)[Internet]. 2016;18(3 (71)):302-309. Available from: https://sid.ir/paper/685297/en

IEEE: Copy

NARGES LABIBZADEH, MOHSEN EMADEDIN, ROGHAYEH FAZELI, FATEMEH MOHSENI, SEYYEDEH ESMAT HOSSEINI, REZA MOGHADASALI, SOURA MARDPOUR, VAJIHEH AZIMIAN, MAEDE GHORBANI LIASTANI, ALI MIRAZIMI BAFGHI, MOHAMADREZA BAGHABAN ESLAMINEJAD, and NASSER AGHDAMI, “MESENCHYMAL STROMAL CELLS IMPLANTATION IN COMBINATION WITH PLATELET LYSATE PRODUCT IS SAFE FOR RECONSTRUCTION OF HUMAN LONG BONE NONUNION,” CELL JOURNAL (YAKHTEH), vol. 18, no. 3 (71), pp. 302–309, 2016, [Online]. Available: https://sid.ir/paper/685297/en

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