MOLECULAR GENETICS AND GENE THERAPY IN OVARIAN CANCER

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NOORI DALOII MOHAMMAD REZA; RASHVAND ZAHRA

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Journal: Internal Medicine Today Year:2010 | Volume:16 | Issue:3 (49) Page(s): 5-19

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Information Journal Paper

Title

MOLECULAR GENETICS AND GENE THERAPY IN OVARIAN CANCER

Author(s)

NOORI DALOII MOHAMMAD REZA | RASHVAND ZAHRA | Issue Writer Certificate

Keywords

CANCERQ2

GENE THERAPYQ2

MOLECULAR GENETICSQ3

OVARIANQ2

Abstract

Ovaries are oval shaped and are located on each side of the uterus in the pelvis. They are not attached to the fallopian tubes but are covered with their end. Surface epithelial tumor (carcinomas) is the most common type of OVARIAN CANCER and is often asymptomatic in its early stages, and due to the lack of early detection strategies, most patients are diagnosed with disseminated disease. Thus, it has the highest mortality rate of CANCERs of the reproductive organ. Several genes are involved in initiation and progression of this CANCER. For example, recent studies have demonstrated that there is mutation in BRAF, KRAS and P53 genes. Also, Germline mutations in BRCA1 and BRCA2 account for the vast majority of families with hereditary breast and OVARIAN CANCER syndrome. On the other hand, siRNA that controls gene expression changes in this CANCER. OVARIAN CANCER is the fifth leading cause of CANCER death in women. Aberrant DNA methylation in OVARIAN CANCER is observed in early CANCER development, especially CpG island DNA methylation, and silencing of genes including tumor suppressors can be detected in DNA circulating in the blood and; hence, it provides the promise of a noninvasive CANCER detection test. Several therapeutic methods are used for this CANCER including Surgery, Antivascular drugs, Hormone therapy and GENE THERAPY. Adenoviruses have been developed as gene delivery vehicles or vectors. Many genes are selected for GENE THERAPY and are studied. For example, Calponin h1 gene, actin binding protein, that cause stability of acting filament, Human PNAS-4 (hPNAS-4), a novel pro-apoptotic gene participating during the early response to DNA damage, RhoB as a tumor suppressor gene and cytokine interleukin-12 gene for induced antiCANCER activity of immune system. In this article, with the use of many articles and our experiments, the MOLECULAR GENETICS and GENE THERAPY in OVARIAN CANCER were reviewed.

Cites

COMPARISON OF THE SERUM LEVEL OF β-HCG, CALCIUM, PHOSPHORUS AND ALKALINE PHOSPHATASE ACTIVITY BETWEEN OVARIAN CANCER PATIENTS AND HEALTHY INDIVIDUALS

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APA: Copy

NOORI DALOII, MOHAMMAD REZA, & RASHVAND, ZAHRA. (2010). MOLECULAR GENETICS AND GENE THERAPY IN OVARIAN CANCER. OFOGH-E-DANESH, 16(3 (49)), 5-19. SID. https://sid.ir/paper/68632/en

Vancouver: Copy

NOORI DALOII MOHAMMAD REZA, RASHVAND ZAHRA. MOLECULAR GENETICS AND GENE THERAPY IN OVARIAN CANCER. OFOGH-E-DANESH[Internet]. 2010;16(3 (49)):5-19. Available from: https://sid.ir/paper/68632/en

IEEE: Copy

MOHAMMAD REZA NOORI DALOII, and ZAHRA RASHVAND, “MOLECULAR GENETICS AND GENE THERAPY IN OVARIAN CANCER,” OFOGH-E-DANESH, vol. 16, no. 3 (49), pp. 5–19, 2010, [Online]. Available: https://sid.ir/paper/68632/en

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