The Toxicity of Synthetic and Biogenic Selenium Nanoparticles on Human Brain Glioblastoma Cell Line: An in vitro Comparison

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Khangholi Shideh; MAHDAVI MEHDI; YAZDI MOHAMMAD HOSSEIN; SHAHVERDI AHMAD REZA

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Journal Paper

Paper Information

Journal: International Journal of Medical Toxicology and Forensic Medicine Year:2020 | Volume:10 | Issue:1 Page(s): 0-0

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Title

The Toxicity of Synthetic and Biogenic Selenium Nanoparticles on Human Brain Glioblastoma Cell Line: An in vitro Comparison

Author(s)

Khangholi Shideh | MAHDAVI MEHDI | YAZDI MOHAMMAD HOSSEIN | SHAHVERDI AHMAD REZA | Issue Writer Certificate

Keywords

Selenium

Biogenic Selenium Nanoparticles

Synthetic Selenium Nanoparticles

Human Brain Glioblastoma Cell Line

Abstract

Background: Brain tumors can be serious and life-threatening when they are treated effectively. Many therapeutic approaches, such as chemotherapy, radiotherapy, and surgery have been used to treat brain tumors. In this regard, Selenium supplements have been reported effective. Methods: Selenium Nanoparticles (SeNPs) were produced in two forms of synthetic and biogenic to evaluate their cytotoxicity on brain glioblastoma cell lines. A-172 cell line was cultured in Dulbecco's Modified Eagle Medium (DMEM) medium. The cytotoxicity of the synthetic and biogenic SeNP was assessed by MTT assay. Results: There was a significant difference between the group treated with biogenic and synthetic SeNP compared with non-treated cells after 24, 48, and 72 h. Both biogenic and synthetic SeNP increased Bax gene and decreased Bcl-2 gene expression. Conclusion: It seems that biogenic SeNP was more lethal than its synthetic form. Therefore, it should be considered that the method of NP construction may be an important parameter for its bioactivity.

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APA: Copy

Khangholi, Shideh, MAHDAVI, MEHDI, & SHAHVERDI, AHMAD REZA. (2020). The Toxicity of Synthetic and Biogenic Selenium Nanoparticles on Human Brain Glioblastoma Cell Line: An in vitro Comparison. INTERNATIONAL JOURNAL OF MEDICAL TOXICOLOGY AND FORENSIC MEDICINE, 10(1), 0-0. SID. https://sid.ir/paper/687076/en

Vancouver: Copy

Khangholi Shideh, MAHDAVI MEHDI, SHAHVERDI AHMAD REZA. The Toxicity of Synthetic and Biogenic Selenium Nanoparticles on Human Brain Glioblastoma Cell Line: An in vitro Comparison. INTERNATIONAL JOURNAL OF MEDICAL TOXICOLOGY AND FORENSIC MEDICINE[Internet]. 2020;10(1):0-0. Available from: https://sid.ir/paper/687076/en

IEEE: Copy

Shideh Khangholi, MEHDI MAHDAVI, and AHMAD REZA SHAHVERDI, “The Toxicity of Synthetic and Biogenic Selenium Nanoparticles on Human Brain Glioblastoma Cell Line: An in vitro Comparison,” INTERNATIONAL JOURNAL OF MEDICAL TOXICOLOGY AND FORENSIC MEDICINE, vol. 10, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/687076/en

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