Evaluation of Antioxidant and Anticancer Effects of Nanoemulsions Prepared Using Dill Essential Oil

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Tavakkol Afshari Haleh Sadat; HOMAYOUNI TABRIZI MASOUD; ARDALAN TOURAN

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2019 | Volume:22 | Issue:4 Page(s): 40-51

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Information Journal Paper

Title

Evaluation of Antioxidant and Anticancer Effects of Nanoemulsions Prepared Using Dill Essential Oil

Author(s)

Tavakkol Afshari Haleh Sadat | HOMAYOUNI TABRIZI MASOUD | ARDALAN TOURAN | Issue Writer Certificate

Keywords

NanoemulsionQ1

DillQ1

AntioxidantQ2

AnticancerQ1

Abstract

the field of nanotechnology. They have been designed for clinical and therapeutic applications. Since the therapeutic efficacy of cancer is measured by the ability of the drug to reduce and eliminate tumors without damaging healthy tissues, Nanoemulsions can be useful as a targeted drug carrier. Therefore, we are going to study the Antioxidant and Anticancer effects of Nanoemulsions prepared using Dill essential oil. Methods and Materials Evaluate the Antioxidant properties, we used DPPH (1, 1-diphenyl-2-picrylhydrazyl) and ABTS (2, 2'-azino-bis[3-ethylbenzothiazoline-6-sulphonic acid]) tests. We also applied MTT assay for the evaluation of induced cytotoxicity in liver hepatocellular carcinoma cells and normal human umbilical vein endothelial cells. Ethical Considerations The Research Ethics Committee of Islamic Azad University (Mashhad Branch) approved this study (Code: IR. IAU. MSHD. REC. 1398. 027). Results Nanoemulsions prepared using Dill essential oil has a good potential for inhibiting DPPH (IC50=500 μ g/mL) and ABTS (IC50=420 μ g/mL) radicals. Nanoemulsions also caused a little toxicity to both cell lines. Nanoemulsions reduced cell viability in a dose-dependent manner and the cytotoxicity induced to cancer cells was higher than normal cells. Conclusion The present study indicates that Nanoemulsions prepared by Dill essential oil will have the potential to become a therapeutic strategy for diseases caused by oxidative stress.

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APA: Copy

Tavakkol Afshari, Haleh Sadat, HOMAYOUNI TABRIZI, MASOUD, & ARDALAN, TOURAN. (2019). Evaluation of Antioxidant and Anticancer Effects of Nanoemulsions Prepared Using Dill Essential Oil. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 22(4 ), 40-51. SID. https://sid.ir/paper/68853/en

Vancouver: Copy

Tavakkol Afshari Haleh Sadat, HOMAYOUNI TABRIZI MASOUD, ARDALAN TOURAN. Evaluation of Antioxidant and Anticancer Effects of Nanoemulsions Prepared Using Dill Essential Oil. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2019;22(4 ):40-51. Available from: https://sid.ir/paper/68853/en

IEEE: Copy

Haleh Sadat Tavakkol Afshari, MASOUD HOMAYOUNI TABRIZI, and TOURAN ARDALAN, “Evaluation of Antioxidant and Anticancer Effects of Nanoemulsions Prepared Using Dill Essential Oil,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 22, no. 4 , pp. 40–51, 2019, [Online]. Available: https://sid.ir/paper/68853/en

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