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Title

EFFECTS OF GENISTEIN AND SWIMMING EXERCISE ON SPATIAL MEMORY AND EXPRESSION OF MICRORNA 132, BDNF, AND IGF-1 GENES IN THE HIPPOCAMPUS OF OVARIECTOMIZED RATS

Pages

  856-862

Abstract

 Objective(s): The aim of the present study was to investigate the effects of GENISTEIN and EXERCISE on the SPATIAL MEMORY and expression of microRNA-132, BDNF, and IGF-1 in the hippocampus of ovariectomized rats.Materials and Methods: Sixty animals were divided into six groups of control, sham, OVARIECTOMY (OVX), ovariectomized with 8 weeks of GENISTEIN administration (OVX.G), with 8 weeks of swimming training (OVX.E), and with 8 weeks of both of them (OVX.G.E). The effect of GENISTEIN and/or EXERCISE was evaluated by measuring microRNA-132, BDNF, and IGF-1 expression levels in the hippocampus tissue. Grafts were analyzed using Real-time polymerase chain reaction for microRNA-132, BDNF, IGF-1, and SPATIAL MEMORY via a Morris water maze (MWM).Results: Our findings showed that OVARIECTOMY decreased the expression of microRNA-132, BDNF, and IGF-1 in the hippocampus (P<0.05) in comparison with the sham group as well as performance in the water maze (P<0.05). Also according to results ovariectomized groups that were treated with GENISTEIN/EXERCISE or both of them showed significant difference in expression of microRNA-132, BDNF, and IGF-1 in the hippocampus (P<0.05) and decreased latency in MWM (P<0.05) compared with the OVX group but combination treatment was more effective in the OVX.G.E group in comparison with OVX.E and OVX.G groups.Conclusion: Overall our results emphasized that combination treatment with GENISTEIN and EXERCISE could improve microRNA-132, BDNF, and IGF-1 expression in the hippocampus as well as the SPATIAL MEMORY of ovariectomized rats. These effects may have beneficial impacts on the menopausal period.

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    APA: Copy

    HABIBI, PARISA, BABRI, SHIRIN, AHMADIASL, NASSER, & YOUSEFI, HADI. (2017). EFFECTS OF GENISTEIN AND SWIMMING EXERCISE ON SPATIAL MEMORY AND EXPRESSION OF MICRORNA 132, BDNF, AND IGF-1 GENES IN THE HIPPOCAMPUS OF OVARIECTOMIZED RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(8), 856-862. SID. https://sid.ir/paper/688634/en

    Vancouver: Copy

    HABIBI PARISA, BABRI SHIRIN, AHMADIASL NASSER, YOUSEFI HADI. EFFECTS OF GENISTEIN AND SWIMMING EXERCISE ON SPATIAL MEMORY AND EXPRESSION OF MICRORNA 132, BDNF, AND IGF-1 GENES IN THE HIPPOCAMPUS OF OVARIECTOMIZED RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(8):856-862. Available from: https://sid.ir/paper/688634/en

    IEEE: Copy

    PARISA HABIBI, SHIRIN BABRI, NASSER AHMADIASL, and HADI YOUSEFI, “EFFECTS OF GENISTEIN AND SWIMMING EXERCISE ON SPATIAL MEMORY AND EXPRESSION OF MICRORNA 132, BDNF, AND IGF-1 GENES IN THE HIPPOCAMPUS OF OVARIECTOMIZED RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 8, pp. 856–862, 2017, [Online]. Available: https://sid.ir/paper/688634/en

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