SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING STUDIES AND BIOLOGICAL EVALUATION OF SOME NOVEL HYBRIDS BASED ON QUINAZOLINONE, BENZOFURAN AND IMIDAZOLIUM MOIETIES AS POTENTIAL CYTOTOXIC AND ANTIMICROBIAL AGENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ASADI PARVIN; Khodarahmi Ghadamali; JAHANIAN NAJAFABADI ALI; SAGHAIE LOTFOLLAH; HASSANZADEH FARSHID

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:9 Page(s): 975-989

Download Full-Text

View:

268

Download:

413

Cites:

Information Journal Paper

Title

SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING STUDIES AND BIOLOGICAL EVALUATION OF SOME NOVEL HYBRIDS BASED ON QUINAZOLINONE, BENZOFURAN AND IMIDAZOLIUM MOIETIES AS POTENTIAL CYTOTOXIC AND ANTIMICROBIAL AGENTS

Author(s)

Keywords

ANTIBACTERIAL

BENZOFURAN

CYTOTOXIC

IMIDAZOLIUM SALT

QM/MM DOCKING

QUINAZOLINONE

Abstract

Objective(s): Hybridization of bioactive natural and synthetic compounds is one of the most promising novel approaches for the design of hit and lead compounds with new molecular structures. In this investigation, a series of novel hybrid structures bearing QUINAZOLINONE, BENZOFURAN and imidazolium moieties were designed and synthesized.Materials and Methods: Novel hybrid compounds were prepared and their structures were characterized by spectral and analytical data. In order to evaluate the biological activities, the synthesized hybrid compounds were studied for in vitro ANTIBACTERIAL activity against three Gram positive bacteria (Staphylococcus aureu, Bacillus subtilis, Listeria monocitogenes) and three Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella entritidis) and also, Candida albicans as one yeast-like fungi strain. CYTOTOXIC activities of the synthesized compounds were also evaluated by the MTT assay in the human breast cancer cell line (MCF-7) and finally docking studies of CYTOTOXIC derivatives were performed on aromatase enzyme.Results: The results of antimicrobial activity showed that compound 14e, with two halogen atoms on QUINAZOLINONE and BENZOFURAN was the most active against all the tested strains of microorganisms with the MIC value 16-128 mg/ml. Some of the tested compounds showed good CYTOTOXICity on MCF-7, and compound 14c with IC50=0.59 micromolar (μM) was found to be the most CYTOTOXIC compound among the studied hybrid derivatives. The docking analysis showed acceptable binding interactions for these compounds.Conclusion: Based on the obtained results, the hybrid derivatives of QUINAZOLINONE, BENZOFURAN and imidazolium could be regarded as efficient candidates for further molecular developments of anticancer and antimicrobial agents.

Cites

No record.

References

No record.

Cite

APA: Copy

ASADI, PARVIN, Khodarahmi, Ghadamali, JAHANIAN NAJAFABADI, ALI, SAGHAIE, LOTFOLLAH, & HASSANZADEH, FARSHID. (2017). SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING STUDIES AND BIOLOGICAL EVALUATION OF SOME NOVEL HYBRIDS BASED ON QUINAZOLINONE, BENZOFURAN AND IMIDAZOLIUM MOIETIES AS POTENTIAL CYTOTOXIC AND ANTIMICROBIAL AGENTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(9), 975-989. SID. https://sid.ir/paper/688862/en

Vancouver: Copy

ASADI PARVIN, Khodarahmi Ghadamali, JAHANIAN NAJAFABADI ALI, SAGHAIE LOTFOLLAH, HASSANZADEH FARSHID. SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING STUDIES AND BIOLOGICAL EVALUATION OF SOME NOVEL HYBRIDS BASED ON QUINAZOLINONE, BENZOFURAN AND IMIDAZOLIUM MOIETIES AS POTENTIAL CYTOTOXIC AND ANTIMICROBIAL AGENTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(9):975-989. Available from: https://sid.ir/paper/688862/en

IEEE: Copy

PARVIN ASADI, Ghadamali Khodarahmi, ALI JAHANIAN NAJAFABADI, LOTFOLLAH SAGHAIE, and FARSHID HASSANZADEH, “SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING STUDIES AND BIOLOGICAL EVALUATION OF SOME NOVEL HYBRIDS BASED ON QUINAZOLINONE, BENZOFURAN AND IMIDAZOLIUM MOIETIES AS POTENTIAL CYTOTOXIC AND ANTIMICROBIAL AGENTS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 9, pp. 975–989, 2017, [Online]. Available: https://sid.ir/paper/688862/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops