BIOINFORMATIC PREDICTION OF MIRNAS TARGETING NOTCH1 AND HBX GENES IN CHRONIC HEPATITIS B-INDUCED HEPATOCELLULAR CARCINOMA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MORADI NILOOFAR; PARYAN MEHDI; KHANSARINEJAD BEHZAD; RAFIEI MOHAMMAD; MONDANIZADEH MAHDIEH

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2017 | Volume:19 | Issue:12 (117) Page(s): 89-101

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

798

Download:

Cites:

Information Journal Paper

Title

BIOINFORMATIC PREDICTION OF MIRNAS TARGETING NOTCH1 AND HBX GENES IN CHRONIC HEPATITIS B-INDUCED HEPATOCELLULAR CARCINOMA

Author(s)

Keywords

BIOINFORMATICSQ1

HEPATOCELLULAR CARCINOMAQ1

MICRORNAQ1

Abstract

Background: HEPATOCELLULAR CARCINOMA (HCC) is the third major cause of cancer death worldwide. Hepatitis B virus (HBV) and HBx gene play an important role in the development of HCC by influencing signaling pathways. Since there is no detectable symptom in the early phase of HCC, there is need to find new HCC-specific markers with high sensitivity for early detection and diagnosis of HCC. On the other hand, by the advent and development of bioinformatic sciences, it is now possible to predict miRNAs as biomarkers, and their targets. Therefore, in the present study, based on the results of the bioinformatic software applications with different algorithm, we selected the miRNA targeting HBx and NOTCH1 mRNAs according to higher score, suitable connection with target gene and confirming them in more softwares.Materials and Methods: First, the sequences of NOTCH1 and HBx genes were retrieved from NCBI. Afterwards, several software applications such as TargetScan, mirWalk, miRBase, Miranda, PicTar, miRVir, and DIANA were applied to predict miRNAs.Results: Based on the high scoring by BIOINFORMATICS softwares and suitable targeting, miR-34a were selected to target NOTCH1 and miR-6510, miR-5193 and miR-214 were chosen to targetHBX gene.Conclusion: Because of tumor suppression roles of miR-214 and miR-34a, they probably could be used as therapeutic strategy in cancer researches. It is also seems that the miR-5193 could act as a specific marker in HEPATOCELLULAR CARCINOMA.

Cites

Bioinformatic Prediction of miRNAs Targeting APRIL and BAFF Genes in Chronic Lymphocytic Leukemia

References

No record.

Cite

APA: Copy

MORADI, NILOOFAR, PARYAN, MEHDI, KHANSARINEJAD, BEHZAD, RAFIEI, MOHAMMAD, & MONDANIZADEH, MAHDIEH. (2017). BIOINFORMATIC PREDICTION OF MIRNAS TARGETING NOTCH1 AND HBX GENES IN CHRONIC HEPATITIS B-INDUCED HEPATOCELLULAR CARCINOMA. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 19(12 (117)), 89-101. SID. https://sid.ir/paper/68891/en

Vancouver: Copy

MORADI NILOOFAR, PARYAN MEHDI, KHANSARINEJAD BEHZAD, RAFIEI MOHAMMAD, MONDANIZADEH MAHDIEH. BIOINFORMATIC PREDICTION OF MIRNAS TARGETING NOTCH1 AND HBX GENES IN CHRONIC HEPATITIS B-INDUCED HEPATOCELLULAR CARCINOMA. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;19(12 (117)):89-101. Available from: https://sid.ir/paper/68891/en

IEEE: Copy

NILOOFAR MORADI, MEHDI PARYAN, BEHZAD KHANSARINEJAD, MOHAMMAD RAFIEI, and MAHDIEH MONDANIZADEH, “BIOINFORMATIC PREDICTION OF MIRNAS TARGETING NOTCH1 AND HBX GENES IN CHRONIC HEPATITIS B-INDUCED HEPATOCELLULAR CARCINOMA,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 19, no. 12 (117), pp. 89–101, 2017, [Online]. Available: https://sid.ir/paper/68891/en

Related Journal Papers