STUDY ON THE TOXICITY EFFECTS OF ZINC OXIDE NANOPARTICLES ON HEMATOLOGICAL AND SERUM PARAMETERS IN MICE

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SHEYDAEI PARVIN; BAYRAMI ABOLFAZL; azizian Yashar; PARVINROO SHADI

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2017 | Volume:19 | Issue:10 (115) Page(s): 39-47

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Title

STUDY ON THE TOXICITY EFFECTS OF ZINC OXIDE NANOPARTICLES ON HEMATOLOGICAL AND SERUM PARAMETERS IN MICE

Author(s)

SHEYDAEI PARVIN | BAYRAMI ABOLFAZL | azizian Yashar | PARVINROO SHADI | Issue Writer Certificate

Keywords

BALB/C MICEQ1

HEMOTOLOGICAL FACTORSQ2

SERUM FACTORSQ1

ZINC OXIDE NANOPARTICLESQ1

Abstract

Background: Nanoparticles are used in various applications due to unique mechanical and physicochemical properties such as their increased surface area to volume ratio and quantum effects. This study was designed to investigate the cytotoxic effects of zinc oxide nanopaticles on hematological and biochemical parameters BALB/C MICE.Materials and Methods: In this experimental study, 28 adult male mice BALB/c, were divided into four groups (one control group and three experimental groups). The mice in the experimental groups orally received ZINC OXIDE NANOPARTICLES with doses of 50, 100 and 300 mg/kg for 14 days. The control group received distillated water only. On 15th day, some hematological and biochemical parameters were studied on the blood samples collected.Results: Results showed that ZINC OXIDE NANOPARTICLES cause changes in blood cells. In high concentration, nanoparticles increased some of factors such as white blood cells, hemoglubin, MCV and neutrophil and besides decreased amount of RBCs, pLTs, hematocrit, lymphocytes, glucose and kratenin significantly (p<0.05).Conclusion: The findings showed that ZINC OXIDE NANOPARTICLES cause harmful effects due to the considerable variations in hematological and serum parameters in mice in a dose-dependent way.

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APA: Copy

SHEYDAEI, PARVIN, BAYRAMI, ABOLFAZL, azizian, Yashar, & PARVINROO, SHADI. (2017). STUDY ON THE TOXICITY EFFECTS OF ZINC OXIDE NANOPARTICLES ON HEMATOLOGICAL AND SERUM PARAMETERS IN MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 19(10 (115)), 39-47. SID. https://sid.ir/paper/68927/en

Vancouver: Copy

SHEYDAEI PARVIN, BAYRAMI ABOLFAZL, azizian Yashar, PARVINROO SHADI. STUDY ON THE TOXICITY EFFECTS OF ZINC OXIDE NANOPARTICLES ON HEMATOLOGICAL AND SERUM PARAMETERS IN MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;19(10 (115)):39-47. Available from: https://sid.ir/paper/68927/en

IEEE: Copy

PARVIN SHEYDAEI, ABOLFAZL BAYRAMI, Yashar azizian, and SHADI PARVINROO, “STUDY ON THE TOXICITY EFFECTS OF ZINC OXIDE NANOPARTICLES ON HEMATOLOGICAL AND SERUM PARAMETERS IN MICE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 19, no. 10 (115), pp. 39–47, 2017, [Online]. Available: https://sid.ir/paper/68927/en

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