SERUM LEVEL OF CHEMERIN IN PATIENTS WITH BREAST CANCER

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Nourbakhsh Parisa; MERZAEI REZVAN; YEGANEHFARD FATEMEH; MOSAYEBI GHASEM

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Paper Information

Journal: Journal of Arak University Medical Sciences Year:2016 | Volume:19 | Issue:5 (110) Page(s): 86-91

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Title

SERUM LEVEL OF CHEMERIN IN PATIENTS WITH BREAST CANCER

Author(s)

Nourbakhsh Parisa | MERZAEI REZVAN | YEGANEHFARD FATEMEH | MOSAYEBI GHASEM | Issue Writer Certificate

Keywords

ADIPOKINEQ1

BREAST CANCERQ1

CHEMERINQ1

Abstract

Background: BREAST CANCER is one of the major causes of cancer- related death and the most common solid malignancy in women worldwide. CHEMERIN as a new ADIPOKINE has an inflammatory activity that initiates inflammation via chemotaxis of immature DCs and macrophages. This study aimed to evaluate the level of CHEMERIN in patients with BREAST CANCER.Materials and Methods: In this cross-sectional study that was performed as a case- control study, we enrolled 45 patients with BREAST CANCER in Vali-asr hospital from June to December 2015 (age range, 18-60 years) and 40 healthy volunteers as a control group (age range, 22-56 years). The patients with invasive breast were selected before mastectomy. The level of serum CHEMERIN was measured by ELISA kit.Results: The results showed that the mean serum CHEMERIN level in the BREAST CANCER patients (1536 ±608 ng/L) was significantly lower than the normal individuals (1919±544 ng/L), (p=0.04). There is no correlation between the level of CHEMERIN with body weight, stage of disease, duration of disease and the number of white and red blood cells.Conclusion: With due attention to the inflammatory role of CHEMERIN, decreasing the serum CHEMERIN level in patients with BREAST CANCER may be related to the consumption of CHEMERIN in the inflammatory responses or immunosuppression by tumor. The low level of chemrerin may be suitable for tumor growth and progression.

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APA: Copy

Nourbakhsh, Parisa, MERZAEI, REZVAN, YEGANEHFARD, FATEMEH, & MOSAYEBI, GHASEM. (2016). SERUM LEVEL OF CHEMERIN IN PATIENTS WITH BREAST CANCER. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 19(5 (110)), 86-91. SID. https://sid.ir/paper/68930/en

Vancouver: Copy

Nourbakhsh Parisa, MERZAEI REZVAN, YEGANEHFARD FATEMEH, MOSAYEBI GHASEM. SERUM LEVEL OF CHEMERIN IN PATIENTS WITH BREAST CANCER. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;19(5 (110)):86-91. Available from: https://sid.ir/paper/68930/en

IEEE: Copy

Parisa Nourbakhsh, REZVAN MERZAEI, FATEMEH YEGANEHFARD, and GHASEM MOSAYEBI, “SERUM LEVEL OF CHEMERIN IN PATIENTS WITH BREAST CANCER,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 19, no. 5 (110), pp. 86–91, 2016, [Online]. Available: https://sid.ir/paper/68930/en

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