THE PROTECTIVE EFFECT OF QUINCE (CYDONIA OBLONGA MILLER) LEAF EXTRACT ON LOCOMOTOR ACTIVITY AND ANXIETY-LIKE BEHAVIORS IN A KETAMINE MODEL OF SCHIZOPHRENIA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HAJIZADEH MOGHADDAM AKBAR; KIANMEHR ASGHAR

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2016 | Volume:19 | Issue:5 (110) Page(s): 31-41

Download Full-Text

Persian Verion

View:

747

Download:

Cites:

Information Journal Paper

Title

THE PROTECTIVE EFFECT OF QUINCE (CYDONIA OBLONGA MILLER) LEAF EXTRACT ON LOCOMOTOR ACTIVITY AND ANXIETY-LIKE BEHAVIORS IN A KETAMINE MODEL OF SCHIZOPHRENIA

Author(s)

HAJIZADEH MOGHADDAM AKBAR | KIANMEHR ASGHAR | Issue Writer Certificate

Keywords

HYPERLOCOMOTOR ACTIVITYQ2

KETAMINEQ1

MICEQ1

QUINCE LEAF EXTRACTQ2

SCHIZOPHRENIAQ1

Abstract

Background: SCHIZOPHRENIA is a chronic debilitating psychiatric disorder affecting 1% of the population worldwide. As for key role of free radicals in the development of this disease and that Quince leaf is a natural source of antioxidant substances, this study was aimed to evaluate the protective effects of QUINCE LEAF EXTRACT on locomotor activity and anxiety-like behaviors by an intraperitoneal injection of KETAMINE in male MICE in a KETAMINE model of SCHIZOPHRENIA.Materials and Methods: In the experimental research, male adult MICE were divided into six groups including: control, Sham (received water orally and saline intraperitoneally), psychosis group (received 10 mg/kg/day KETAMINE i.p. for 10 days) and treated psychosis groups (received 50, 100 and 150 mg/kg/day). Treated groups received hydroalcoholic QUINCE LEAF EXTRACT orally for 3 weeks before injection of KETAMINE. Extract gavages continue for 5 days after the last KETAMINE injection. Locomotor activity and anxiety-like behavioral changes were measured in the open- field test.Results: The results showed that chronic administration of KETAMINE increases horizontal locomotor activity and anxiety like behaviors (p≤0.001) and pretreatment of QUINCE LEAF EXTRACT effectively decreases horizontal locomotor activity (p<0.001) and increases duration that spends in middle area of Open field (p<0.01) and vertical ocomotor activity (p<0.001).Conclusion: The results of this research showed that chronic administration of QUINCE LEAF EXTRACT improves locomotor disorder and induced anxiety- like behaviors by having antioxidant properties in a KETAMINE model of SCHIZOPHRENIA.

Cites

No record.

References

Cite

APA: Copy

HAJIZADEH MOGHADDAM, AKBAR, & KIANMEHR, ASGHAR. (2016). THE PROTECTIVE EFFECT OF QUINCE (CYDONIA OBLONGA MILLER) LEAF EXTRACT ON LOCOMOTOR ACTIVITY AND ANXIETY-LIKE BEHAVIORS IN A KETAMINE MODEL OF SCHIZOPHRENIA. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 19(5 (110)), 31-41. SID. https://sid.ir/paper/68933/en

Vancouver: Copy

HAJIZADEH MOGHADDAM AKBAR, KIANMEHR ASGHAR. THE PROTECTIVE EFFECT OF QUINCE (CYDONIA OBLONGA MILLER) LEAF EXTRACT ON LOCOMOTOR ACTIVITY AND ANXIETY-LIKE BEHAVIORS IN A KETAMINE MODEL OF SCHIZOPHRENIA. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;19(5 (110)):31-41. Available from: https://sid.ir/paper/68933/en

IEEE: Copy

AKBAR HAJIZADEH MOGHADDAM, and ASGHAR KIANMEHR, “THE PROTECTIVE EFFECT OF QUINCE (CYDONIA OBLONGA MILLER) LEAF EXTRACT ON LOCOMOTOR ACTIVITY AND ANXIETY-LIKE BEHAVIORS IN A KETAMINE MODEL OF SCHIZOPHRENIA,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 19, no. 5 (110), pp. 31–41, 2016, [Online]. Available: https://sid.ir/paper/68933/en

Related Journal Papers