THE ASSOCIATION OF APOLIPOPROTEIN A1 POLYMORPHISMS WITH DIABETES AND HYPERTENSION IN PATIENTS WITH CORONARY ARTERY DISEASE IN FARS PROVINCE

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HAMIDI LEILA; KHATAMSAZ SAEED; MOKHTARI MOHAMMAD JAVAD; BABAEI BEIGI MOHAMMAD ALI

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Paper Information

Journal: Journal of Arak University Medical Sciences Year:2017 | Volume:20 | Issue:8 (125) Page(s): 20-28

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Title

THE ASSOCIATION OF APOLIPOPROTEIN A1 POLYMORPHISMS WITH DIABETES AND HYPERTENSION IN PATIENTS WITH CORONARY ARTERY DISEASE IN FARS PROVINCE

Author(s)

HAMIDI LEILA | KHATAMSAZ SAEED | MOKHTARI MOHAMMAD JAVAD | BABAEI BEIGI MOHAMMAD ALI | Issue Writer Certificate

Keywords

APOLIPOPROTEIN A1Q1

CORONARY ARTERY DISEASEQ2

DIABETESQ2

HYPERTENSIONQ2

SMOKINGQ2

Abstract

Background: CORONARY ARTERY DISEASE (CAD) is a multifactorial disorder, which remains asymptomatic for many years. Genetic and environmental factors are involved to this disease. In the past years, the role of apo lipoproteins and their polymorphisms has been identified in the diseases. The aim of this study was to evaluate the correlation between gene polymorphisms of apo lipoprotein A1 with DIABETES, HYPERTENSION and cigarette SMOKING in CAD sufferers in Fars province.Materials and Methods: This study evaluates the promoter region polymorphisms up to intron 2 of APOA1 genes in 75 CAD cases and 75 controls. The method used to determine these polymorphisms was PCR sequencing. This case-control study was performed by odds ratio (OR, with a confidence interval of 0.95) to reveal the association of these polymorphisms with HYPERTENSION, DIABETES and SMOKING in CAD patients.Results: Four polymorphisms were identified in this area. The genotypes of AA in 12718466, GA in rs 670, TC in rs5070 and CC in rs 5069 had the highest frequency in all patient groups and controls. There was a significant association in Rs12718466 between control group with diabetic group (p=0.033).Conclusion: The results of this study indicated that DIABETES, HYPERTENSION and cigarette SMOKING had no effects in initiation and aggravation of CAD.

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APA: Copy

HAMIDI, LEILA, KHATAMSAZ, SAEED, MOKHTARI, MOHAMMAD JAVAD, & BABAEI BEIGI, MOHAMMAD ALI. (2017). THE ASSOCIATION OF APOLIPOPROTEIN A1 POLYMORPHISMS WITH DIABETES AND HYPERTENSION IN PATIENTS WITH CORONARY ARTERY DISEASE IN FARS PROVINCE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(8 (125) ), 20-28. SID. https://sid.ir/paper/69032/en

Vancouver: Copy

HAMIDI LEILA, KHATAMSAZ SAEED, MOKHTARI MOHAMMAD JAVAD, BABAEI BEIGI MOHAMMAD ALI. THE ASSOCIATION OF APOLIPOPROTEIN A1 POLYMORPHISMS WITH DIABETES AND HYPERTENSION IN PATIENTS WITH CORONARY ARTERY DISEASE IN FARS PROVINCE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;20(8 (125) ):20-28. Available from: https://sid.ir/paper/69032/en

IEEE: Copy

LEILA HAMIDI, SAEED KHATAMSAZ, MOHAMMAD JAVAD MOKHTARI, and MOHAMMAD ALI BABAEI BEIGI, “THE ASSOCIATION OF APOLIPOPROTEIN A1 POLYMORPHISMS WITH DIABETES AND HYPERTENSION IN PATIENTS WITH CORONARY ARTERY DISEASE IN FARS PROVINCE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 8 (125) , pp. 20–28, 2017, [Online]. Available: https://sid.ir/paper/69032/en

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