GENETIC POLYMORPHISM GSTM1 BY PCR AND SUSCEPTIBILITY TO STOMACH CANCER

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YAD ELAHI M.; SAADAT M.; OMIDVARI SH.; SAADAT I.

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Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2002 | Volume:4 | Issue:4 (17) Page(s): 8-14

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Title

GENETIC POLYMORPHISM GSTM1 BY PCR AND SUSCEPTIBILITY TO STOMACH CANCER

Author(s)

YAD ELAHI M. | SAADAT M. | OMIDVARI SH. | SAADAT I. | Issue Writer Certificate

Keywords

GASTRIC CANCERQ2

GLUTATHIONE S-TRANSFERASEQ4

GENETIC POLYMORPHISMQ4

PCRQ3

Abstract

Introduction: Glutathion S-transferases (GST) are enzyme encoded by a multigene family and have important roles in detoxification of some strong carcinogenes. Human GSTs are categorized into four groups namely, α, µ, π and θ. GSTM1 is a member of GSTµ. Previous studies revealed that absence of GSTM1 protein associates with increased risk of development of several malignancies.Materials and Methods: In the current study, the relationship between GSTM1 GENETIC POLYMORPHISM and the susceptibility for being involved by gastric carcinoma was explored. Forty patients with gastric carcinoma and 80 normal individuals (control group) were studied. GSTM1 GENETIC POLYMORPHISM between exons 5 and 6 was explored using a PCR technique for each patient a questionnaire including gender, age, cigarette smoking, habit, and history of neoplasia in first-degree relatives was completed.Results: The relative frequencies of null genotype in the control group and GASTRIC CANCER were 31.2% and 60% respectively. There was a statistically significant (X2= 9.21; P<0.05) assessment between GSTM1 null genotype and development of gastric carcinoma.Conclusion: Not mentioning the GSTM1 genotype, cigarette smoking and a positive family history had significant correlations with development of stomach malignancy.

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APA: Copy

YAD ELAHI, M., SAADAT, M., OMIDVARI, SH., & SAADAT, I.. (2002). GENETIC POLYMORPHISM GSTM1 BY PCR AND SUSCEPTIBILITY TO STOMACH CANCER. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 4(4 (17)), 8-14. SID. https://sid.ir/paper/69132/en

Vancouver: Copy

YAD ELAHI M., SAADAT M., OMIDVARI SH., SAADAT I.. GENETIC POLYMORPHISM GSTM1 BY PCR AND SUSCEPTIBILITY TO STOMACH CANCER. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2002;4(4 (17)):8-14. Available from: https://sid.ir/paper/69132/en

IEEE: Copy

M. YAD ELAHI, M. SAADAT, SH. OMIDVARI, and I. SAADAT, “GENETIC POLYMORPHISM GSTM1 BY PCR AND SUSCEPTIBILITY TO STOMACH CANCER,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 4, no. 4 (17), pp. 8–14, 2002, [Online]. Available: https://sid.ir/paper/69132/en

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