CALYCOSIN ATTENUATES DEXTRAN SULFATE SODIUM (DSS)-INDUCED EXPERIMENTAL COLITIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

CHAO LIU; ZHENG PENGYUAN; XIA LIU; YONG YU; LU GAOFENG; TANG FUAI; ZHAO ZHIGUO

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:9 Page(s): 1056-1062

Download Full-Text

View:

258

Download:

417

Cites:

Information Journal Paper

Title

CALYCOSIN ATTENUATES DEXTRAN SULFATE SODIUM (DSS)-INDUCED EXPERIMENTAL COLITIS

Author(s)

Keywords

COLITIS

CALYCOSIN

FREE RADICAL

INFLAMMATORY CELL

NF-κB

SIGNALING PATHWAY

Abstract

Objective(s): Inflammatory bowel disease (IBD) results from dysregulation of intestinal mucosal immunity. It is an incurable disease that affects millions of people worldwide. Developing new strategies for the treatment of COLITIS has been a major challenge. Here, we report the effect of CALYCOSIN, a plant-derived flavonoid, in successfully managing COLITIS in murine model.Material and Methods: In vivomodel of COLITIS was induced using 2.5% (w/v) dextran sodium sulfate (DSS, 36, 000 to 50, 000 Mw). Body weight and disease activity index (DAI) were evaluated every day. Hematoxylin-Eosin (H& E) staining was used to estimate the effect of CALYCOSIN on DSS-induced colon damage. The levels of proinflammatory genes and mRNA expression were determined using real-time PCR, whereas the proinflammatory cytokines were assessed with ELISA. The content of other parameters including myeloperoxidase (MPO), glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA) were also evaluated. Western blot assay was further used to determine the effect of CALYCOSIN on both NF-kB and mitogen activated protein kinases (MAPK) pathways.Results: The results showed that CALYCOSIN prevented weight loss and shortening of the colon length, maintained an intact mucosa, increased GSH and SOD activities, and decreased MDA levels. The drug also significantly inhibited proinflammatory cytokine mRNA expression and decreased MPO activity. Additionally, it remarkably inhibited NF-kB pathway and c-Jun N-terminal kinase (JNK) phosphorylation with no effect on p38 and extracellular signal-regulated kinase (ERK1/2) phosphorylation levels in colon tissue.Conclusion: These findings revealed that CALYCOSIN successfully ameliorated the effect of DSS-induced COLITIS in mice, which could be associated with NF-kB and JNK pathway modulations

Cites

No record.

References

No record.

Cite

APA: Copy

CHAO, LIU, ZHENG, PENGYUAN, XIA, LIU, YONG, YU, LU, GAOFENG, TANG, FUAI, & ZHAO, ZHIGUO. (2017). CALYCOSIN ATTENUATES DEXTRAN SULFATE SODIUM (DSS)-INDUCED EXPERIMENTAL COLITIS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(9), 1056-1062. SID. https://sid.ir/paper/691498/en

Vancouver: Copy

CHAO LIU, ZHENG PENGYUAN, XIA LIU, YONG YU, LU GAOFENG, TANG FUAI, ZHAO ZHIGUO. CALYCOSIN ATTENUATES DEXTRAN SULFATE SODIUM (DSS)-INDUCED EXPERIMENTAL COLITIS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(9):1056-1062. Available from: https://sid.ir/paper/691498/en

IEEE: Copy

LIU CHAO, PENGYUAN ZHENG, LIU XIA, YU YONG, GAOFENG LU, FUAI TANG, and ZHIGUO ZHAO, “CALYCOSIN ATTENUATES DEXTRAN SULFATE SODIUM (DSS)-INDUCED EXPERIMENTAL COLITIS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 9, pp. 1056–1062, 2017, [Online]. Available: https://sid.ir/paper/691498/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops