مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

SWERTIA LONGIFOLIA BOISS HAS BENEFICIAL EFFECTS ON HEPATIC AND RENAL FUNCTIONS IN DIABETIC RATS

Pages

  163-171

Abstract

 Introduction: DIABETES is a multifactorial syndrome with high prevalence which may induce serious disorders in the body organs like the LIVER and KIDNEY. This study aimed to compare the effects of the alcoholic extract of the aerial parts of SWERTIA LONGIFOLIA BOISSon blood glucose, lipid profiles and LIVER and KIDNEY function tests in STREPTOZOTOCIN-induced DIABETES.Methods: Thirty five male rats were put into five groups: control, diabetic control and three diabetic experimental groups which were gavaged with alcoholic extract of SWERTIA LONGIFOLIA BOISSat doses of 100 and 200 mg/kg BW and glibenclamide at a dose of 10 mg/kg BW, respectively. DIABETES was induced by intraperitoneal injection of STREPTOZOTOCIN. At the end of day 21 blood samples were collected from all groups and the blood factors were measured and analyzed.Results: The levels of creatinine, urea, LIVER enzymes, cholesterol and low density lipoprotein increased in the diabetic control group compared to the control, while the mentioned factors in the groups receivingSwertia longifolia Boiss alcoholic extract decreased significantly (P<0.05). In the experimental group receiving glibenclamide, the levels of creatinine, urea and lipid profiles also decreased, while the levels of LIVER enzymes and insulin significantly increased (P<0.05).Conclusion: The consumption of the alcoholic extract of the aerial parts of SWERTIA LONGIFOLIA BOISSby lowering lipid profiles, LIVER enzymes, creatinine and urea as well as increasing insulin levels had beneficial effects on the hepatic and renal functions and could alleviate the symptoms of increased glucose and hyperlipidemia in diabetic rats.

Cites

References

Cite

APA: Copy

ZAREI, ALI, MALEKIRAD, ALI AKBAR, ABDOLLAHI, MOHAMMAD, VAEZI, GHOLAMHASSAN, & CHANGIZI ASHTIYANI, SAEED. (2017). SWERTIA LONGIFOLIA BOISS HAS BENEFICIAL EFFECTS ON HEPATIC AND RENAL FUNCTIONS IN DIABETIC RATS. PHYSIOLOGY AND PHARMACOLOGY, 21(2), 163-171. SID. https://sid.ir/paper/691583/en

Vancouver: Copy

ZAREI ALI, MALEKIRAD ALI AKBAR, ABDOLLAHI MOHAMMAD, VAEZI GHOLAMHASSAN, CHANGIZI ASHTIYANI SAEED. SWERTIA LONGIFOLIA BOISS HAS BENEFICIAL EFFECTS ON HEPATIC AND RENAL FUNCTIONS IN DIABETIC RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2017;21(2):163-171. Available from: https://sid.ir/paper/691583/en

IEEE: Copy

ALI ZAREI, ALI AKBAR MALEKIRAD, MOHAMMAD ABDOLLAHI, GHOLAMHASSAN VAEZI, and SAEED CHANGIZI ASHTIYANI, “SWERTIA LONGIFOLIA BOISS HAS BENEFICIAL EFFECTS ON HEPATIC AND RENAL FUNCTIONS IN DIABETIC RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 21, no. 2, pp. 163–171, 2017, [Online]. Available: https://sid.ir/paper/691583/en

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