The Oral Post-Treatment Effect of Hydroethanolic Extract of Origanum Vulgare on Acute Kidney Injury Caused by Gentamicin in Rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HAJIHASHEMI SAEED; RAJABI RAZIEH; Ghiasabadi Farahani Atefeh

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Arak University Medical Sciences Year:2019 | Volume:22 | Issue:5 Page(s): 18-31

Download Full-Text

Persian Verion

View:

686

Download:

312

Cites:

Information Journal Paper

Title

The Oral Post-Treatment Effect of Hydroethanolic Extract of Origanum Vulgare on Acute Kidney Injury Caused by Gentamicin in Rats

Author(s)

HAJIHASHEMI SAEED | RAJABI RAZIEH | Ghiasabadi Farahani Atefeh | Issue Writer Certificate

Keywords

GentamicinQ1

NephrotoxicityQ1

Origanum VulgareQ1

RatQ1

Abstract

Background and AimGentamicin antibiotic has some side effects such as Nephrotoxicity. The aim of this study was to evaluate the post-treatment effects of using hydroethanolic extract of Origanum Vulgare (OV) on Nephrotoxicity caused by Gentamicin. Methods & MaterialsIn this study, 32 male Wistar Rats were divided into four groups of control (n=8), Gentamicin (n=8; 100 mg/kg/day intraperitoneally for 8 days and gavage of distilled water for 2 days), OV extract group (intraperitoneal injection of normal saline for 8 days and using 40 mg/kg OV extract by gavage for 2 days), and Gentamicin+ OV extract (intraperitoneal injection of Gentamicin 100 mg/kg/day for 8 days and using 40 mg/kg OV extract by gavage for 2 days). The concentRation of urea, creatinine, sodium, potassium and osmolarity were measured in plasma and urine samples. The right kidney was used to measure Malondialdehyde (MDA) and Ferric Reducing Antioxidant Power (FRAP). Ethical ConsideRations This article was obtained from a research proposal approved by the Research Ethics Committee of Arak University of Medical Sciences (Code: IR. ARAKMU. REC. 1394. 284) Results Post-treatment administRation of hydroethanolic extract of OV significantly decreased the concentRation of urea, creatinine, absolute sodium excretion, relative sodium and potassium excretion, and MDA levels but significantly increased creatinine, urine osmolality and FRAP levels. Conclusion Oral administRation of OV extract as post-treatment method improved Nephrotoxicity caused by Gentamicin use by reducing oxidative stress of oxygen free radicals and lipid peroxidation in the affected kidneys.

Cites

Protective Effects of Co-Treatment With Hydroethanolic Extract of Origanum Vulgare on Gentamicin-Induced Renal Toxicity in Rats

References

Cite

APA: Copy

HAJIHASHEMI, SAEED, RAJABI, RAZIEH, & Ghiasabadi Farahani, Atefeh. (2019). The Oral Post-Treatment Effect of Hydroethanolic Extract of Origanum Vulgare on Acute Kidney Injury Caused by Gentamicin in Rats. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 22(5 ), 18-31. SID. https://sid.ir/paper/69174/en

Vancouver: Copy

HAJIHASHEMI SAEED, RAJABI RAZIEH, Ghiasabadi Farahani Atefeh. The Oral Post-Treatment Effect of Hydroethanolic Extract of Origanum Vulgare on Acute Kidney Injury Caused by Gentamicin in Rats. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2019;22(5 ):18-31. Available from: https://sid.ir/paper/69174/en

IEEE: Copy

SAEED HAJIHASHEMI, RAZIEH RAJABI, and Atefeh Ghiasabadi Farahani, “The Oral Post-Treatment Effect of Hydroethanolic Extract of Origanum Vulgare on Acute Kidney Injury Caused by Gentamicin in Rats,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 22, no. 5 , pp. 18–31, 2019, [Online]. Available: https://sid.ir/paper/69174/en

Related Journal Papers