EFFECT OF VITAMIN E ON THE INHIBITION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN C57BL/6 MOUSE

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MOSAYEBI GHASEM; GHAZAVI A.; KHAZAEI M.R.; PAYANI M.A.

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Title

EFFECT OF VITAMIN E ON THE INHIBITION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN C57BL/6 MOUSE

Author(s)

MOSAYEBI GHASEM | GHAZAVI A. | KHAZAEI M.R. | PAYANI M.A. | Issue Writer Certificate

Keywords

MULTIPLE SCLEROSISQ2

EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITISQ3

VITAMIN EQ3

NITRIC OXIDEQ2

URIC ACIDQ3

C57BL/6 MOUSEQ3

Abstract

Introduction: Free radical-mediated peroxidation of biological molecules, such as lipids, is implicated in the pathogenesis of MULTIPLE SCLEROSIS and it's animal model experimental allergic encephalomyelitis (EAE). Low concentration of antioxidant VITAMIN E has been observed in serum of MULTIPLE SCLEROSIS. However, it is not known whether VITAMIN E has protective effect in EAE. VITAMIN E may inhibit EAE by effect on the level of URIC ACID and NITRIC OXIDE (NO) production. Materials and Methods: In this experimental study some male C57BL/6 mice were placed in two therapeutic groups (n=8 per group) with age and weight-matched as follow: 1) VITAMIN E-treated EAE mice (10mg/kg/every two days of VITAMIN E given i.p from day-3 until day+19 after disease induction, 2) Non-treated EAE mice (EAE control) received vehicle alone with same schedule. In addition, 5 age and weight-matched male C57BL/6 mice served as normal (non-EAE) controls. Clinical score of disease, URIC ACID and NO levels of the groups were analysed.Results: Results showed that VITAMIN E-treated mice had significantly less clinical score of EAE (4±0.8) than non-treated EAE induced mice (5.3±0.44), (p<0.01). Also, there was difference at the onset day of the disease between VITAMIN E-treated and non-treated EAE-induced mice (day 13±1 and day 11±1, respectively), although was not significant. Concentration of URIC ACID in VITAMIN E treated mice were significantly lower than EAE control (p<0.001). There was no difference at the level of NO between the groups.Conclusion: VITAMIN E had no effect on NO level, but decreased serum URIC ACID level. It suggests that VITAMIN E can reduce or delay the onset of EAE by increasing URIC ACID consumption.

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APA: Copy

MOSAYEBI, GHASEM, GHAZAVI, A., KHAZAEI, M.R., & PAYANI, M.A.. (2006). EFFECT OF VITAMIN E ON THE INHIBITION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN C57BL/6 MOUSE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 9(1 (34)), 68-75. SID. https://sid.ir/paper/69209/en

Vancouver: Copy

MOSAYEBI GHASEM, GHAZAVI A., KHAZAEI M.R., PAYANI M.A.. EFFECT OF VITAMIN E ON THE INHIBITION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN C57BL/6 MOUSE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2006;9(1 (34)):68-75. Available from: https://sid.ir/paper/69209/en

IEEE: Copy

GHASEM MOSAYEBI, A. GHAZAVI, M.R. KHAZAEI, and M.A. PAYANI, “EFFECT OF VITAMIN E ON THE INHIBITION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN C57BL/6 MOUSE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 9, no. 1 (34), pp. 68–75, 2006, [Online]. Available: https://sid.ir/paper/69209/en

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