IN SILICO SCREENING HEPATITIS B VIRUS DNA POLYMERASE INHIBITORS FROM MEDICINAL PLANTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NOSRATI MOKHTAR; SHAKERAN ZAHRA; SHAKERAN ZAINAB

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2017 | Volume:20 | Issue:5 (122) Page(s): 89-102

Download Full-Text

Persian Verion

View:

831

Download:

Cites:

Information Journal Paper

Title

IN SILICO SCREENING HEPATITIS B VIRUS DNA POLYMERASE INHIBITORS FROM MEDICINAL PLANTS

Author(s)

NOSRATI MOKHTAR | SHAKERAN ZAHRA | SHAKERAN ZAINAB | Issue Writer Certificate

Keywords

DNA POLYMERASEQ1

HEPATITIS B VIRUSQ1

IN SILICOQ1

MEDICINAL PLANTQ1

Abstract

Background: HEPATITIS B VIRUS infection (HBV) is a significant global health problem and is a major cause of morbidity and mortality worldwide. Therefore, currently, introducing novel anti Hepatitis B drugs is taken into consideration. This study was planned to IN SILICO screening novel HEPATITIS B VIRUS DNA POLYMERASE inhibitors from two MEDICINAL PLANTs Terminalis chebulaand Caesalpinia sappan.Materials and Methods: This is a descriptive-analytic study. In the study, three dimensional structure of the HEPATITIS B VIRUS DNA POLYMERASE was predicted using homology modeling method. A set of phytochemicals from mentioned plants were retrieved from Pubchem database in SDF format. IN SILICO screening was carried out using molecular docking between mentioned phytochemicals and modeled polymerase by iGemdock 2.1 software.Results: Results of the study confirmed that all evaluated ligands have appropriate interactions to the polymerase with least toxicity and without genotoxicity potential. Results also showed that most interactions occur in reverse transcriptase domain which located in 354-694 area in the amino acid sequence of tested polymerase. Analysis of energy and amino acids involved in ligand-polymerase interaction revealed that Terchebin, Chebulinic Acid and Terflavin A have more effective interaction with the polymerase in compared to other ligands.Conclusion: Based on the results it can be concluded that evaluated compounds could be good candidates for in vitro and in vivo research in order to develop novel anti-Hepatitis Bdrugs.

Cites

References

Cite

APA: Copy

NOSRATI, MOKHTAR, SHAKERAN, ZAHRA, & SHAKERAN, ZAINAB. (2017). IN SILICO SCREENING HEPATITIS B VIRUS DNA POLYMERASE INHIBITORS FROM MEDICINAL PLANTS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(5 (122)), 89-102. SID. https://sid.ir/paper/69292/en

Vancouver: Copy

NOSRATI MOKHTAR, SHAKERAN ZAHRA, SHAKERAN ZAINAB. IN SILICO SCREENING HEPATITIS B VIRUS DNA POLYMERASE INHIBITORS FROM MEDICINAL PLANTS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;20(5 (122)):89-102. Available from: https://sid.ir/paper/69292/en

IEEE: Copy

MOKHTAR NOSRATI, ZAHRA SHAKERAN, and ZAINAB SHAKERAN, “IN SILICO SCREENING HEPATITIS B VIRUS DNA POLYMERASE INHIBITORS FROM MEDICINAL PLANTS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 5 (122), pp. 89–102, 2017, [Online]. Available: https://sid.ir/paper/69292/en

Related Journal Papers