The Effects of Endurance Training on Gene Expression of VEGF and VEGFR2 of Cardiac Tissue in Type 2 Diabetic Male Wistar

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

VALIZADEH SARA; MOTAMEDI PEZHMAN; KARAMI HADI; RAJABI HAMID; RAJABI HAMID

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Arak University Medical Sciences Year:2018 | Volume:21 | Issue:6 (135) Page(s): 107-118

Download Full-Text

Persian Verion

View:

585

Download:

Cites:

Information Journal Paper

Title

The Effects of Endurance Training on Gene Expression of VEGF and VEGFR2 of Cardiac Tissue in Type 2 Diabetic Male Wistar

Author(s)

Keywords

AngiogenesisQ1

Endurance trainingQ1

VEGFQ1

Abstract

Background and Aim: Type 2 diabetes exerts an anti-Angiogenesis effects on the cardiac tissue. The aim of present study was to investigate the effects of Endurance training on gene expression of VEGF and VEGFR2 of cardiac tissue in type 2 diabetic male wistar rats. Materials and Methods: 36 male wistar rats were randomly divided into three groups, Diabetic Endurance training (DET), Diabetic Control (DC) and Healthy Control (HC). Type 2 diabetes was induced by intraperitoneal injection of STZ. The Endurance training included 10 weeks, 5 sessions per week running at speed of 27 m/min and intensity of 75% VO2max for 20-30min in 1st week and reached to 27 m/min and intensity of 75% VO2max for 60 min/day in 10th weeks. The gene expression of VEGF and VEGFR2 were examined by Real-Time PCR AND Western Blotting. Findings: The results of Real-Time PCR showed that the Endurance training caused increase in VEGF mRNA (p<0. 05) and VEGFR2 mRNA (p<0. 05) compared to DC group. The results of Western Blotting also indicated that the Endurance training induced increase in VEGF protein expression (p<0. 05) compared to DC group and there was no significant change in expression of VEGFR2 protein (p>0. 05). Conclusion: Type 2 diabetes impairs the Angiogenesis process in diabetic cardiac. It appears that Endurance training has positive impact on Angiogenesis and it can cause the improvement of diabetic cardiac.

Cites

The effects of 8 weeks aerobic training on HIF-1α , miR-21 and VEGF gene expression in female Balb/c with breast cancer

References

Cite

APA: Copy

VALIZADEH, SARA, MOTAMEDI, PEZHMAN, KARAMI, HADI, & RAJABI, HAMID. (2018). The Effects of Endurance Training on Gene Expression of VEGF and VEGFR2 of Cardiac Tissue in Type 2 Diabetic Male Wistar. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 21(6 (135) ), 107-118. SID. https://sid.ir/paper/69318/en

Vancouver: Copy

VALIZADEH SARA, MOTAMEDI PEZHMAN, KARAMI HADI, RAJABI HAMID. The Effects of Endurance Training on Gene Expression of VEGF and VEGFR2 of Cardiac Tissue in Type 2 Diabetic Male Wistar. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2018;21(6 (135) ):107-118. Available from: https://sid.ir/paper/69318/en

IEEE: Copy

SARA VALIZADEH, PEZHMAN MOTAMEDI, HADI KARAMI, and HAMID RAJABI, “The Effects of Endurance Training on Gene Expression of VEGF and VEGFR2 of Cardiac Tissue in Type 2 Diabetic Male Wistar,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 21, no. 6 (135) , pp. 107–118, 2018, [Online]. Available: https://sid.ir/paper/69318/en

Related Journal Papers