ASSOCIATION STUDY OF IL16GENE POLYMORPHISM WITH THE RISK OF SPORADIC ALZHEIMER’S DISEASE

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KHOSHBAKHT T.; SOOSANABADI M.; NEISHABOURY M.; KARIMLOU M.; KHORRAMKHORSHID H.R.

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Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2014 | Volume:17 | Issue:7 (88) Page(s): 41-47

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Title

ASSOCIATION STUDY OF IL16GENE POLYMORPHISM WITH THE RISK OF SPORADIC ALZHEIMER’S DISEASE

Author(s)

Keywords

ALZHEIMER’S DISEASEQ1

ASSOCIATION STUDYQ2

IL16Q2

POLYMORPHISMQ2

Abstract

Background: Interleukin-16 (IL16) is an important regulator of T cell activation and was reported to act as achemo-attractant agent. There are evidences that IL16 can control the neuroinflammatory processes in ALZHEIMER’S DISEASE (AD). This study was performed to show whether the IL-16 genepolymorphism, rs11556218 is associated with the risk of sporadic AD in Iranian population.Materials and Methods: Totally, 148 AD patients and 137non-dementia controls were recruited in this case-control study. Genotyping of rs11556218 T/Gpolymorphism was performed by PCR-RFLP method using the NdeI restriction enzyme.Results: Statistical analysis of rs11556218 genotypes showed a protective effect against AD in the heterozygote genotype (p=0.001, OR=0.16 (0.1-0.28)). Frequency of rs11556218 allele T was higher in patients than controls (p=0.001, OR=0.32 (0.21-0.49)).Conclusion: Our results indicate thatrs11556218 POLYMORPHISM has a protective role in the development of sporadic AD in Iranian population.

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APA: Copy

KHOSHBAKHT, T., SOOSANABADI, M., NEISHABOURY, M., KARIMLOU, M., & KHORRAMKHORSHID, H.R.. (2014). ASSOCIATION STUDY OF IL16GENE POLYMORPHISM WITH THE RISK OF SPORADIC ALZHEIMER’S DISEASE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 17(7 (88)), 41-47. SID. https://sid.ir/paper/69334/en

Vancouver: Copy

KHOSHBAKHT T., SOOSANABADI M., NEISHABOURY M., KARIMLOU M., KHORRAMKHORSHID H.R.. ASSOCIATION STUDY OF IL16GENE POLYMORPHISM WITH THE RISK OF SPORADIC ALZHEIMER’S DISEASE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2014;17(7 (88)):41-47. Available from: https://sid.ir/paper/69334/en

IEEE: Copy

T. KHOSHBAKHT, M. SOOSANABADI, M. NEISHABOURY, M. KARIMLOU, and H.R. KHORRAMKHORSHID, “ASSOCIATION STUDY OF IL16GENE POLYMORPHISM WITH THE RISK OF SPORADIC ALZHEIMER’S DISEASE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 17, no. 7 (88), pp. 41–47, 2014, [Online]. Available: https://sid.ir/paper/69334/en

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