THE INHIBITION OF NUCLEUS ACCUMBENS CHOLINERGIC RECEPTORS DECREASED MEMORY RETENTION IN RAT

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REZAYOF A.; ZARRINDAST M.R.; DARBANDI N.

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Paper Information

Journal: Journal of Arak University Medical Sciences Year:2014 | Volume:17 | Issue:6 (87) Page(s): 19-30

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Title

THE INHIBITION OF NUCLEUS ACCUMBENS CHOLINERGIC RECEPTORS DECREASED MEMORY RETENTION IN RAT

Author(s)

REZAYOF A. | ZARRINDAST M.R. | DARBANDI N. | Issue Writer Certificate

Keywords

ATROPINEQ2

MECAMYLAMINEQ2

MEMORYQ2

MORPHINEQ2

PASSIVE AVOIDANCE LEARNINGQ2

SCOPOLAMINEQ2

Abstract

Background: It is well known that MORPHINE influence learning and MEMORY processes. The Nucleus accumbens (N.ac) which has an important role in reward participates in MORPHINE-induced impairment of MEMORY retention. Considering the cholinergic system is involved in the effects of MORPHINE on learning and MEMORY, in the present study, the effects of intra-N.ac injections of acetylcholine receptor antagonists alone or with MORPHINE on MEMORY retention and MORPHINE-induced MEMORY has been investigated in rats.Materials and Methods: In this original research animals were bilaterally cannulated in the N.ac and a step-through passive avoidance task was used for the assessment of MEMORY retention.Results: Post-training subcutaneous administration of MORPHINE dose dependently decreased the learning and induced amnesia. The administration of the same dose of MORPHINE as pre-test treatment induced state-dependent learning. Pre-test intra- N.ac administration of ATROPINE, SCOPOLAMINE and MECAMYLAMINE in different doses alone cannot affect on MEMORY retention. While, pretest intra- N.ac injection of these drugs before the administration of MORPHINE dose dependently inhibited MORPHINE state-dependent learning. The level of statistical significance was set at p<0.05.Conclusion: The processes of learning in animals can be affected by MORPHINE and the opioids produce state-dependent learning. Moreover, it can be concluded that inactivation of the muscarinic and nicotinic acethylcoline receptors in the N.ac are involved in mediating MORPHINE state-dependent learning.

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APA: Copy

REZAYOF, A., ZARRINDAST, M.R., & DARBANDI, N.. (2014). THE INHIBITION OF NUCLEUS ACCUMBENS CHOLINERGIC RECEPTORS DECREASED MEMORY RETENTION IN RAT. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 17(6 (87)), 19-30. SID. https://sid.ir/paper/69359/en

Vancouver: Copy

REZAYOF A., ZARRINDAST M.R., DARBANDI N.. THE INHIBITION OF NUCLEUS ACCUMBENS CHOLINERGIC RECEPTORS DECREASED MEMORY RETENTION IN RAT. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2014;17(6 (87)):19-30. Available from: https://sid.ir/paper/69359/en

IEEE: Copy

A. REZAYOF, M.R. ZARRINDAST, and N. DARBANDI, “THE INHIBITION OF NUCLEUS ACCUMBENS CHOLINERGIC RECEPTORS DECREASED MEMORY RETENTION IN RAT,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 17, no. 6 (87), pp. 19–30, 2014, [Online]. Available: https://sid.ir/paper/69359/en

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