Bovine Leukaemia Virus Tax Antigen Identification in Human Lymphoma Tissue: Possibility of Onco-protein Gene Transmission

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Taghadosi Camellia; Kojouri Gholam Ali; AHADI ALI MOHAMMAD; Hashemi Bahremani Mohammad; Kojouri Abdolnabi

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Journal: Research in Molecular Medicine Year:2019 | Volume:7 | Issue:2 Page(s): 25-32

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Title

Bovine Leukaemia Virus Tax Antigen Identification in Human Lymphoma Tissue: Possibility of Onco-protein Gene Transmission

Author(s)

Keywords

Lymphoma

Nested PCR

RTnested-PCR

Tax

Abstract

Background: Bovine Leukaemia Virus (BLV) is the cause of Enzootic Bovine Leukosis (EBL) which belongs to retroviruses including Human T-cell leukaemia virus and simian T-lymphotropic virus. Due to this familiarity, the possibility of BLV transfer from animal production to humans may exist. Materials and Methods: In the present study, formalin-fixed, paraffin-embedded and fresh human Lymphomas tissues were used for detecting the BLV Tax genome and BLV Tax expression using nested-PCR and RT-nested-PCR. Results: Nested-PCR evaluation showed that 9 of 41 samples contained Tax region of BLV genome, of which eight samples belonged to high grade diffuse large cell Lymphoma (B-cell type). Also, the results of RT-nested-PCR showed the BLV Tax expression in 2 of 5 high grade diffuse large cell Lymphoma (B-cell type) samples. Conclusion: These findings explain the possible relation between BLV infection and the occurrence of some types of human Lymphomas for the first time.

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APA: Copy

Taghadosi, Camellia, Kojouri, Gholam Ali, AHADI, ALI MOHAMMAD, Hashemi Bahremani, Mohammad, & Kojouri, Abdolnabi. (2019). Bovine Leukaemia Virus Tax Antigen Identification in Human Lymphoma Tissue: Possibility of Onco-protein Gene Transmission. RESEARCH IN MOLECULAR MEDICINE, 7(2), 25-32. SID. https://sid.ir/paper/693662/en

Vancouver: Copy

Taghadosi Camellia, Kojouri Gholam Ali, AHADI ALI MOHAMMAD, Hashemi Bahremani Mohammad, Kojouri Abdolnabi. Bovine Leukaemia Virus Tax Antigen Identification in Human Lymphoma Tissue: Possibility of Onco-protein Gene Transmission. RESEARCH IN MOLECULAR MEDICINE[Internet]. 2019;7(2):25-32. Available from: https://sid.ir/paper/693662/en

IEEE: Copy

Camellia Taghadosi, Gholam Ali Kojouri, ALI MOHAMMAD AHADI, Mohammad Hashemi Bahremani, and Abdolnabi Kojouri, “Bovine Leukaemia Virus Tax Antigen Identification in Human Lymphoma Tissue: Possibility of Onco-protein Gene Transmission,” RESEARCH IN MOLECULAR MEDICINE, vol. 7, no. 2, pp. 25–32, 2019, [Online]. Available: https://sid.ir/paper/693662/en

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