ASSAY OF RELATION BETWEEN THE VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION AND BREAST CANCER TUMOR FORMATION

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SADEGHI M.; HOJATI Z.; GHAEDI K.

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Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2014 | Volume:17 | Issue:8 (89) Page(s): 27-34

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Title

ASSAY OF RELATION BETWEEN THE VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION AND BREAST CANCER TUMOR FORMATION

Author(s)

SADEGHI M. | HOJATI Z. | GHAEDI K. | Issue Writer Certificate

Keywords

BREAST CANCERQ2

GENE EXPRESSION PPATTERN ANALYSISQ2

VASCULAR ENDOTHELIAL GROWTH FACTORQ1

Abstract

Background: VASCULAR ENDOTHELIAL GROWTH FACTOR (vegf) is one of the most important regulator of angiogenesis, there are some reports about the relation of VEGF over expression and progression of tumor in several cancers. The aim of this study is assay of four VEGF isoforms expression in BREAST CANCER tumor samples.Materials and Methods: 25 BREAST CANCER tumor samples and 25 health samples were used in this study, mRNA was extracted from each sample and then cDNA was made. The expression of four isoforms: VEGF121, VEGF165, VEGF183 and VEGF189 were measured by real time reverse transcription PCR (RT-PCR) and gel electrophoresis.Results: among the four isoforms, VEGF165 and VEGF 121 had maximum and VEGF 183 and VEGF 189 minimum expression level in all samples. The total expression level of VEGF had a significant increase in tumor samples in comparison with the control samples (4.6, p<0.01).Conclusion: there is a significant relation between the VEGF over expression and BREAST CANCER tumor formation, which it can be used as a prognosis marker of BREAST CANCER in future.

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APA: Copy

SADEGHI, M., HOJATI, Z., & GHAEDI, K.. (2014). ASSAY OF RELATION BETWEEN THE VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION AND BREAST CANCER TUMOR FORMATION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 17(8 (89)), 27-34. SID. https://sid.ir/paper/69561/en

Vancouver: Copy

SADEGHI M., HOJATI Z., GHAEDI K.. ASSAY OF RELATION BETWEEN THE VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION AND BREAST CANCER TUMOR FORMATION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2014;17(8 (89)):27-34. Available from: https://sid.ir/paper/69561/en

IEEE: Copy

M. SADEGHI, Z. HOJATI, and K. GHAEDI, “ASSAY OF RELATION BETWEEN THE VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION AND BREAST CANCER TUMOR FORMATION,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 17, no. 8 (89), pp. 27–34, 2014, [Online]. Available: https://sid.ir/paper/69561/en

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