ANALYSIS OF GLU298ASP ENOS GENE POLYMORPHISM IN PATIENTS WITH GASTRIC CANCER IN THE GUILAN POPULATION

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ARJMAND KOLUKHI Z.; SALEHI Z.; MASHAYEKHI F.; NAJAFI B.; MIRPOOR SH.

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Journal: Journal of Arak University Medical Sciences Year:2014 | Volume:17 | Issue:8 (89) Page(s): 53-62

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Title

ANALYSIS OF GLU298ASP ENOS GENE POLYMORPHISM IN PATIENTS WITH GASTRIC CANCER IN THE GUILAN POPULATION

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Keywords

ENOSQ1

GASTRIC CANCERQ2

GENETIC POLYMORPHISMQ2

NITRIC OXIDE SYNTHASESQ2

Abstract

Background: Nitric oxide is synthesized in endothelial cells by ENOS and acts as a pleiotropic regulator involved in carcinogenesis. Most GASTRIC CANCERs develop from stomach epithelial cells; therefore, NO may play a role in their development. Polymorphisms of ENOS have been shown to be associated with cancer susceptibility. In the present study, we investigated the association of the ENOS genotypes with GASTRIC CANCER risk in Guilan Population.Materials and Methods: In this Case-Control study, we analyzed the Glu298Asp polymorphism of ENOS in 87 patients with GASTRIC CANCER and 90 healthy controls. The genotyping of ENOS polymorphism was performed using polymerase chain reaction–restriction fragment length polymorphism assays. All statistical analyses were conducted by the MedCalc statistical software.Results: No association between the ENOS genotypes and GASTRIC CANCER risk was found. Among the 87 patients, 45 had Glu/Glu, 38 were Glu/Asp, and 4 were Asp/Asp. In the control group, 44 had Glu/Glu, 40 were Glu/Asp, and 6 were Asp/Asp. We found no significant differences in allele and genotype frequencies between control and patient specimens.Conclusion: We found that there was No association between this polymorphism and GASTRIC CANCER risk. Results suggest that ENOS polymorphism may play a role in inhibition of GASTRIC CANCER. However, larger population-based studies are needed for clarifying the role of ENOS polymorphism in GASTRIC CANCER.

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APA: Copy

ARJMAND KOLUKHI, Z., SALEHI, Z., MASHAYEKHI, F., NAJAFI, B., & MIRPOOR, SH.. (2014). ANALYSIS OF GLU298ASP ENOS GENE POLYMORPHISM IN PATIENTS WITH GASTRIC CANCER IN THE GUILAN POPULATION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 17(8 (89)), 53-62. SID. https://sid.ir/paper/69565/en

Vancouver: Copy

ARJMAND KOLUKHI Z., SALEHI Z., MASHAYEKHI F., NAJAFI B., MIRPOOR SH.. ANALYSIS OF GLU298ASP ENOS GENE POLYMORPHISM IN PATIENTS WITH GASTRIC CANCER IN THE GUILAN POPULATION. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2014;17(8 (89)):53-62. Available from: https://sid.ir/paper/69565/en

IEEE: Copy

Z. ARJMAND KOLUKHI, Z. SALEHI, F. MASHAYEKHI, B. NAJAFI, and SH. MIRPOOR, “ANALYSIS OF GLU298ASP ENOS GENE POLYMORPHISM IN PATIENTS WITH GASTRIC CANCER IN THE GUILAN POPULATION,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 17, no. 8 (89), pp. 53–62, 2014, [Online]. Available: https://sid.ir/paper/69565/en

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