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Information Journal Paper

Title

Study of Sperm Chromatin in Infertile Men with Globozoospermia: A Systematic Review Article

Author(s)

 TAVALAEE MARZIYEH | ESKANDARI NASIM | NASR ESFAHANI MOHAMMAD HOSSEIN | Issue Writer Certificate 

Pages

  126-138

Abstract

 Background and Aim: Globozoospermia is a severe sperm morphological abnormality in men that characterized by round-headed spermatozoa with low or absence acrosome structure in their sperm samples. In these men, high level of DNA Damage and abnormal chromatin packaging also were reported. These deficiencies can consider as the main etiologies of infertility in these infertile men. The aim of this article is to study the sperm chromatin structure in infertile men with globozoospermia. Materials and Methods: In this systematic review article, 77 articles related to Protamine deficiency, DNA Damage, Aneuploidy in globozoospermic men were collected via data bases such as PubMed, Google Scholar, Scopus since 1971-2017. Ethical Considerations: This study with research ethics code IR. ACECR. ROYAN. REC. 1396. 204 have been approved at research ethics committee of Royan Institute. Findings: Mean percentage of sperm DNA fragmentation and Protamine deficiency were significantly higher in infertile men with globozoospermia compared to fertile men. While, the results of chromosome Aneuploidy were controversial in infertile men with globozoospermia within studies. Conclusion: In addition to abnormal acrosome formation, as main etiology of failed fertilization, in infertile men with globozoospermia, high level of sperm abnormal chromatin packaging and DNA Damage can be also involved in this phenomenon. Therefore, antioxidant therapy before intra-cytoplasmic sperm injection technique were suggested for these individuals to minimize sperm chromatin damage.

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    APA: Copy

    TAVALAEE, MARZIYEH, ESKANDARI, NASIM, & NASR ESFAHANI, MOHAMMAD HOSSEIN. (2019). Study of Sperm Chromatin in Infertile Men with Globozoospermia: A Systematic Review Article. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 22(1 (137) ), 126-138. SID. https://sid.ir/paper/69578/en

    Vancouver: Copy

    TAVALAEE MARZIYEH, ESKANDARI NASIM, NASR ESFAHANI MOHAMMAD HOSSEIN. Study of Sperm Chromatin in Infertile Men with Globozoospermia: A Systematic Review Article. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2019;22(1 (137) ):126-138. Available from: https://sid.ir/paper/69578/en

    IEEE: Copy

    MARZIYEH TAVALAEE, NASIM ESKANDARI, and MOHAMMAD HOSSEIN NASR ESFAHANI, “Study of Sperm Chromatin in Infertile Men with Globozoospermia: A Systematic Review Article,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 22, no. 1 (137) , pp. 126–138, 2019, [Online]. Available: https://sid.ir/paper/69578/en

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