STUDY OF ANTIMUTAGENIC AND ANTICANCER EFFECT OF LACTIC ACID BACTERIA ISOLATED FROM TARKHINEH BY AMES TEST

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MEHRABIAN S.; TAJABADI EBRAHIMI M.; ABBAS AHMADI M.; BAHRAMI H.

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2012 | Volume:15 | Issue:7 (66) Page(s): 72-79

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Title

STUDY OF ANTIMUTAGENIC AND ANTICANCER EFFECT OF LACTIC ACID BACTERIA ISOLATED FROM TARKHINEH BY AMES TEST

Author(s)

MEHRABIAN S. | TAJABADI EBRAHIMI M. | ABBAS AHMADI M. | BAHRAMI H. | Issue Writer Certificate

Keywords

LACTOBACILLIQ2

MICROSOMEQ3

NEOPLASMQ2

PROBIOTICQ2

Abstract

Background: Deaths due to cancer have been increasing in many countries in recent years.Probiotics are live microorganisms that have beneficial effects on consumer’s health. The aim of this study was to investigate antimutagenic and anticancer effects of LACTOBACILLI strains isolated from Tarkhineh in order to select potential PROBIOTIC strains.Materials and Methods: In this experimental study, 25 strains of Lactobacillus that had previously been isolated from Tarkhineh were used. Antimutagenicity test was performed based on proposed method of Ames. The results of the test were individuated after comparison between samples (suspensions of LACTOBACILLI) and positive (sodium azide) and negative (distilled water) controls. SPSS version 16 was used for statistical analysis.Results: Antimutagenic activity was observed only in four strains of LACTOBACILLI. The inhibitory percentage in the four strains of LACTOBACILLI, in its highest level was equal to 60.38 and in its lowest percentage equal to 39.37%. Also, the inhibitory percentage of mutation among the four strains in the presence of MICROSOME were significantly different (P<0.05) than the absence of MICROSOME. Adding the MICROSOME of rat liver (S9) proved the anticancer effects of four LACTOBACILLI strains.Conclusion: Of the 25 strains of LACTOBACILLI, 4 strains which had the highest antimutagenicity effects were chosen as the potential PROBIOTIC strains.

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APA: Copy

MEHRABIAN, S., TAJABADI EBRAHIMI, M., ABBAS AHMADI, M., & BAHRAMI, H.. (2012). STUDY OF ANTIMUTAGENIC AND ANTICANCER EFFECT OF LACTIC ACID BACTERIA ISOLATED FROM TARKHINEH BY AMES TEST. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 15(7 (66)), 72-79. SID. https://sid.ir/paper/69672/en

Vancouver: Copy

MEHRABIAN S., TAJABADI EBRAHIMI M., ABBAS AHMADI M., BAHRAMI H.. STUDY OF ANTIMUTAGENIC AND ANTICANCER EFFECT OF LACTIC ACID BACTERIA ISOLATED FROM TARKHINEH BY AMES TEST. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2012;15(7 (66)):72-79. Available from: https://sid.ir/paper/69672/en

IEEE: Copy

S. MEHRABIAN, M. TAJABADI EBRAHIMI, M. ABBAS AHMADI, and H. BAHRAMI, “STUDY OF ANTIMUTAGENIC AND ANTICANCER EFFECT OF LACTIC ACID BACTERIA ISOLATED FROM TARKHINEH BY AMES TEST,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 15, no. 7 (66), pp. 72–79, 2012, [Online]. Available: https://sid.ir/paper/69672/en

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