A STUDY OF THE THERMAL STABILITY OF MEASLES VACCINE PRODUCED BY AIK-C STRAIN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAYESTEHPOUR M.; SHAHKARAMI M.K.; SHAFYI A.; TAQAVIAN M.; KAMALI JAMIL R.; ESNA ASHARI F.; MOHAMMADI A.; SHAHBAZI R.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2012 | Volume:15 | Issue:4 (63) Page(s): 27-33

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,119

Download:

Cites:

Information Journal Paper

Title

A STUDY OF THE THERMAL STABILITY OF MEASLES VACCINE PRODUCED BY AIK-C STRAIN

Author(s)

Keywords

HALF-LIFEQ2

MEASLESQ2

VACCINEQ2

VIRUS TITERQ2

Abstract

Background: Noticing the sensitivity of MEASLES virus to temperature and light, maintaining its stability is highly important in live VACCINEs. The aim of the study is to evaluate the stability of MEASLES VACCINE produced by AIK-C strain.Materials and Methods: In this experimental study, three lyophilized VACCINE vials were incubated at 37oC for one week and their stability was evaluated via accelerated test. In addition, reconstituted VACCINEs were incubated at 4oC, 25oC, and 37oC for 0, 4, 8, 12, 16 hours after reconstitution and their remaining infectious VIRUS TITER was measured using CCID50 method. HALF-LIFE of the reconstituted MEASLES VACCINE was evaluated according to linear regression analysis.Results: When the reconstituted VACCINE was incubated at 4oC, 25oC, and 37oC, the titer loss per hour was equal to 0.05, 0.1 and 0.2 Log10 CCID50, respectively. Also, the HALF-LIFE of this VACCINE at these temperatures was 5.31, 2.26, and 1.36 hours, respectively.Conclusion: The loss of potency for MEASLES VACCINE produced by AIK-C strain is 0.33 Log after storage at 37oC for one week, while the reported amounts for commercial VACCINEs such as Mevilin-L, Attenuvax, Edmonston-Zagreb, and Rimevax are 0.7, 0.7, 1 and 0.78, respectively.Lyophilized and reconstituted VACCINE containing AIK-C strain is more stable in comparison with Edmonston B, Schwartz, Biken-CAM, and Leningrad strains. The stability of the reconstituted AIK-C strain VACCINE is similar to Moraten strain at 37oC.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAYESTEHPOUR, M., SHAHKARAMI, M.K., SHAFYI, A., TAQAVIAN, M., KAMALI JAMIL, R., ESNA ASHARI, F., MOHAMMADI, A., & SHAHBAZI, R.. (2012). A STUDY OF THE THERMAL STABILITY OF MEASLES VACCINE PRODUCED BY AIK-C STRAIN. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 15(4 (63)), 27-33. SID. https://sid.ir/paper/69684/en

Vancouver: Copy

SHAYESTEHPOUR M., SHAHKARAMI M.K., SHAFYI A., TAQAVIAN M., KAMALI JAMIL R., ESNA ASHARI F., MOHAMMADI A., SHAHBAZI R.. A STUDY OF THE THERMAL STABILITY OF MEASLES VACCINE PRODUCED BY AIK-C STRAIN. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2012;15(4 (63)):27-33. Available from: https://sid.ir/paper/69684/en

IEEE: Copy

M. SHAYESTEHPOUR, M.K. SHAHKARAMI, A. SHAFYI, M. TAQAVIAN, R. KAMALI JAMIL, F. ESNA ASHARI, A. MOHAMMADI, and R. SHAHBAZI, “A STUDY OF THE THERMAL STABILITY OF MEASLES VACCINE PRODUCED BY AIK-C STRAIN,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 15, no. 4 (63), pp. 27–33, 2012, [Online]. Available: https://sid.ir/paper/69684/en

Related Journal Papers