EFFECT OF REGULAR EXERCISE AND VITAMIN C ON PAIN THRESHOLD IN DIABETIC RATS

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BIGDELI Y.; HEIDARIANPOUR A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: Journal of Arak University Medical Sciences Year:2012 | Volume:15 | Issue:4 (63) Page(s): 11-17

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Information Journal Paper

Title

EFFECT OF REGULAR EXERCISE AND VITAMIN C ON PAIN THRESHOLD IN DIABETIC RATS

Author(s)

BIGDELI Y. | HEIDARIANPOUR A. | Issue Writer Certificate

Keywords

DIABETESQ2

DIABETIC NEUROPATHYQ3

PAIN THRESHOLDQ2

REGULAR EXERCISEQ2

VITAMIN CQ1

Abstract

Background: Peripheral neuropathy is a common complication associated with DIABETES mellitus. It has been shown that oxidative stress is an important etiological factor in neuropathy which contributes to its development, however, the exact pathophysiology underlying this complication is not fully understood. This study was designed to examine the effect of REGULAR EXERCISE and VITAMIN C administration on PAIN THRESHOLD in rats.Materials and Methods: In this experimental study, 36 male Wister rats (220±10 g) were allocated to control and diabetic (control, VITAMIN C, exercise, and exercise+vitamin C) groups.DIABETES was induced by the subcutaneous administration of streptozotocin (60 mg/kg). A week after the induction of DIABETES, the rats were subjected to swimming training and VITAMIN C treatment for 8 weeks. At the end of weeks 3, 5, and 8, Tail-Flick test was done on the rats to assess PAIN THRESHOLD.Data were analyzed using SPSS software.Results: DIABETES significantly decreased PAIN THRESHOLD in the rats. DIABETES-induced hyperalgesia was significantly decreased by training and VITAMIN C. Concurrent effects of training and VITAMIN C on thermal PAIN THRESHOLD were significantly higher than each of them alone.Conclusion: REGULAR EXERCISE together with VITAMIN C administration can be a proper method for preventing thermal hyperalgesia associated with DIABETES. Therefore, they can be effective in the treatment and management of pain.

Cites

ANTINOCICEPTIVE EFFECT OF BRASSICA JUNCEA ON PERIPHERAL NEUROPATHY INDUCED BY DIABETES IN RAT

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APA: Copy

BIGDELI, Y., & HEIDARIANPOUR, A.. (2012). EFFECT OF REGULAR EXERCISE AND VITAMIN C ON PAIN THRESHOLD IN DIABETIC RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 15(4 (63)), 11-17. SID. https://sid.ir/paper/69686/en

Vancouver: Copy

BIGDELI Y., HEIDARIANPOUR A.. EFFECT OF REGULAR EXERCISE AND VITAMIN C ON PAIN THRESHOLD IN DIABETIC RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2012;15(4 (63)):11-17. Available from: https://sid.ir/paper/69686/en

IEEE: Copy

Y. BIGDELI, and A. HEIDARIANPOUR, “EFFECT OF REGULAR EXERCISE AND VITAMIN C ON PAIN THRESHOLD IN DIABETIC RATS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 15, no. 4 (63), pp. 11–17, 2012, [Online]. Available: https://sid.ir/paper/69686/en

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